The present issue of Memórias do Instituto Oswaldo Cruz is entirely devoted to malaria studies as part of the celebration of the centenary of the discovery of the exo-erythrocytic cycle of malaria parasites by Henrique BR Aragão (1879-1956). This third issue of volume 102 contains 23 articles that bring original contributions following investigations performed by researchers from several American, European, Asian, and African countries, dealing with quite a few fields in malariology, from genetics of human plasmodia and anopheline vectors to malaria epidemiology, immunology, and therapy.