| Author | Pereira, Martha Maria | |
| Author | Silva, João José Pereira da | |
| Author | Pinto, Marcelo Alves | |
| Author | Silva, Mauro França da | |
| Author | Machado, Marcelo Pelajo | |
| Author | Lenzi, Henrique Leonel | |
| Author | Marchevsky, Renato Sergio | |
| Access date | 2012-02-28T14:15:30Z | |
| Available date | 2012-02-28T14:15:30Z | |
| Document date | 2005 | |
| Citation | PEREIRA, M. M. et al. Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis. American Journal of Tropical Medicine and Hygiene, v.72, n.1, p. 13-20, 2005. | pt_BR |
| ISSN | 0002-9637 | |
| URI | https://www.arca.fiocruz.br/handle/icict/3783 | |
| Description | Acknowledgments: We thank Antonio José Alves, Emilson Domingues
da Silva, José Mariano da Silva, José Wanderley Pissurno, and
Luzia de Fatima Caputo for their excellent and dedicated technical
support. We also thank the Primate Information Center, University
of Washington (Seattle, WA) for providing bibliographic information
about leptospirosis in primates. | pt_BR |
| Sponsorship | Financial support: This study was supported by grants from the National
Council for Scientific and Technological Development–CNPq,
Brazil. | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | en |
| Rights | open access | |
| Title | Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis | pt_BR |
| Type | Article | |
| Abstract | Experimental infection of marmoset monkeys (Callithrix jacchus) with Leptospira interrogans serovar
Copenhageni showed microscopic patterns of tissue reactions comparable to those seen in the severe forms of human
leptospirosis, including intra-alveolar hemorrhage. The most impressive microscopic changes were seen in the lung and
kidney of animals killed at days 6 and 12 after inoculation. There were extensive and irregular areas of hemorrhage
predominating around main bronchial branches or diffusely spread to the pulmonary parenchyma, as well as severe
tubulointerstitial nephritis. Antibody response detected by the microscopic agglutination test was quantitatively similar
to those seen in humans and paralleled severity of tissue lesions. The distribution of leptospires or antigenic debris in
infected tissues was observed by immunofluorescence and confocal laser scanning microscopy. Large numbers of typical
leptospires were seen in the lumen of proximal renal tubules. Positive reactions showing antigenic debris were closely
associated with sites of tissue damage. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Hemorrhage | pt_BR |
| Subject | Etiology | pt_BR |
| Subject | Leptospirosis | pt_BR |
| Subject | Immunology | pt_BR |
| Subject | Pathology | pt_BR |
| Subject | Animals | pt_BR |
| Subject | Haplorhini | pt_BR |
| DeCS | Haplorrinos | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Hemorragia | pt_BR |
| DeCS | Leptospirose | pt_BR |
| DeCS | Imunologia | pt_BR |
| DeCS | Patologia | pt_BR |
| DeCS | Etiologia | pt_BR |
