| Author | Perales, Jonas | |
| Author | Ferreira, Ana G. C. Neves | |
| Author | Valente, Richard H. | |
| Author | Domont, Gilberto B. | |
| Access date | 2019-12-17T14:15:55Z | |
| Available date | 2019-12-17T14:15:55Z | |
| Document date | 2005 | |
| Citation | PERALES, Jonas et al. Natural inhibitors of snake venom hemorrhagic metalloproteinases. Toxicon, v. 45, p. 1013-1020, 2005. | pt_BR |
| ISSN | 0041-0101 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38652 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Imunidade natural | pt_BR |
| Subject in Portuguese | Proteínas antitóxicas | pt_BR |
| Subject in Portuguese | Metalloproteinase do veneno da serpente | pt_BR |
| Subject in Portuguese | Inibidor da metaloproteinase | pt_BR |
| Title | Natural inhibitors of snake venom hemorrhagic metalloproteinases | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.toxicon.2005.02.028 | |
| Abstract | Metalloproteinases play an important role in the poisoning process by snake venoms. They evoke systemic injury, by
degrading or activating host blood factors, and local damage by acting on endothelial cell surface proteins. Plasma and / or
muscle of venomous and non-venomous snakes as well as of some special mammals possess metalloproteinase inhibitors that
behave as soluble acceptors available for a rapid inhibition of the deleterious action of these enzymes. The purpose of this
review is to describe the state of the art on natural immunity against snake venom metalloproteinases and to overview this field
by discussing the available structural and biological properties of the inhibitors protein / gene families. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Metalloproteinase inhibitor | pt_BR |
| Subject | Antitoxic proteins | pt_BR |
| Subject | Snake venom metalloproteinase | pt_BR |
| Subject | Natural immunity | pt_BR |
| e-ISSN | 1879-3150 | |
| Embargo date | 2025-01-01 | |
