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LOW LEVEL LASER THERAPY PARTIALLY RESTORES TRACHEA MUSCLE RELAXATION RESPONSE IN RATS WITH TUMOR NECROSIS FACTOR ALPHA-MEDIATED SMOOTH AIRWAY MUSCLE DYSFUNCTION
Aimbire, F. et al. | Fecha del documento: 2006
Autor
Aimbire, F.
Bjordal, J. M.
Iversen, V. V.
Albertini, R.
Frigo, L.
Pacheco, M. T. T.
Faria Neto, Hugo Caire C.
Chavantes, M. C.
Labat, R. M.
Martins, R. A. B. Lopes
Afiliación
Institute of Research and Development-IP&D/UNIVAP. São José dos Campos, SP, Brasil.
University of Bergen. Institute of Public Health and Primary Health Care. Section of Physiotherapy Science. Bergen, Norway.
University of Bergen. Haukeland University Hospital. Institute of Biomedicine. Section of Physiology. Bergen, Norway.
Institute of Research and Development-IP&D/UNIVAP. São José dos Campos, SP, Brasil.
Universidade Cruzeiro do Sul. Faculdade de Ciências da Saúde. Laboratório de Histologia e Neuroanatomia. São Miguel Paulista, SP, Brasil.
Institute of Research and Development-IP&D/UNIVAP. São José dos Campos, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Instituto do Coração. Departamento de Laser em Biomedicina. São Paulo, Brasil.
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. Laboratório de Farmacologia e Fototerapia de Inflamação. São Paulo, SP, Brasil.
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. Laboratório de Farmacologia e Fototerapia de Inflamação. São Paulo, SP, Brasil.
Resumen en ingles
Background and Objective: It is unknown if the decreased ability to relax airway smooth muscles in asthma and other inflammatory airways disorders can be influenced by low level laser therapy (LLLT) irradiation. To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats. Study Design/Materials and Methods: Controlled rat study where trachea was dissected and mounted in an organ bath apparatus with or without a TNF-a solution. Results: Low level laser therapy administered perpendicularly to a point in the middle of the dissected trachea with a wavelength of 655 nm and a dose of 2.6 J/cm2, partially restored TSM relaxation response to isoproterenol. Tension reduction was 47.0 % ( 2.85) in the laser-irradiated group compared to 22.0% ( 2.21) in the control group (P < 0.01). Accumulation of cAMP was almost normalized after LLLT at 22.3 pmol/mg ( 2.1) compared to 17.6 pmol/mg ( 2.1) in the non-irradiated control group (P < 0.01). Conclusion: Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol.
Palabras clave en portugues
Terapia a laser de baixo nível
Inflamação
Traquéia
Vias aéreas
 
Palabras clave en ingles
Low level laser therapy
Inflammation
TNF-alpha
Airway
Trachea
 
DeCS
Fator de Necrose Tumoral alfa
Editor
Wiley
Referencia
AIMBIRE, F. et al. Low Level Laser Therapy Partially Restores Trachea Muscle Relaxation Response in Rats With Tumor Necrosis Factor a-Mediated Smooth Airway Muscle Dysfunction. Lasers in Surgery and Medicine, v. 38, p. 773-778, 2006.
DOI
10.1002/lsm.20357
ISSN
0196-8092