Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/3881
Title: Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
Authors: Andrade, Sonia Gumes
Mesquita, Igor Marcelo Oliveira
Jambeiro, Jamile F.
Santos, Isis Fernandes Magalhães
Portella, Renata Siqueira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting Chagas' disease reactivation, submitted to treatment with benznidazole. In the present study, we investigated whether there is a potentiation in the generation of lymphomas in chronically infected mice, treated with immunosuppressive drugs and benznidazole. For this, 142 Swiss mice chronically infected with the 21 SF strain of T. cruzi and 72 normal Swiss mice were used. Both infected and normal mice were divided into experimental groups and submitted to one of the following treatment regimens: benznidazole alone; immunosuppressive drugs (azathioprine, betamethasone and cyclosporin); a combination of immunosuppressive drugs and benznidazole; and untreated controls. In the infected group treated with benznidazole, one mouse developed a non-Hodgkin's lymphoma. This finding has been interpreted as a spontaneous tumor of mice. The study of the chronically infected mice treated with the combination of immunosuppressive drugs and benznidazole demonstrated an absence of lymphomas or other neoplasias. These findings support the indication of benznidazole, as the drug of choice, for immunosuppressed patients that develop a reactivation of Chagas' disease.
Keywords: Trypanosoma cruzi
Experimental Infection
Chemotherapy
Benznidazole
Immunosuppressive Drugs
Non-Hodgkin’s lymphoma
keywords: Trypanosoma cruzi
Infecção Experimental
Quimioterapia
Benzonidazol
Drogas Imunossupressoras
Linfoma não Hodgkin
DeCS: Doença de Chagas/quimioterapia
Imunossupressores/efeitos adversos
Neoplasias/induzido quimicamente
Nitroimidazóis/efeitos adversos
Tripanossomicidas/efeitos adversos
Doença Crônica
Issue Date: 2003
Citation: ANDRADE, S.G. et al. Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias. Revista da Sociedade Brasileira de Medicina Tropical, v. 36, n. 4, p. 441-447, jul.-aug. 2003.
ISSN: 0037-8682
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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