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2025-01-01
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DE NOVO CHROMOSOMAL ABNORMALITIES AND MONTH OF CONCEPTION. DATA FROM THE SOUTHERN HEMISPHERE
Gadow, Enrique et al. | Date Issued: 2006
Author
Gadow, Enrique
Petracchi, Florencia
Poletta, Fernando A.
Castilla, Eduardo E.
Affilliation
Instituto Universitario IUC. Centro de Educacíon Médica e Investigaciones Clínicas CEMIC. Department of Obstetrics and Gynecology. Genetic Unit. Buenos Aires, Argentina.
Instituto Universitario IUC. Centro de Educacíon Médica e Investigaciones Clínicas CEMIC. Department of Obstetrics and Gynecology. Genetic Unit. Buenos Aires, Argentina.
Instituto Universitario IUC. Centro de Educacíon Médica e Investigaciones Clínicas CEMIC. ECLAMC at CEMIC. Buenos Aires, Argentina.
Instituto Universitario IUC. Centro de Educacíon Médica e Investigaciones Clínicas CEMIC. ECLAMC at CEMIC. Buenos Aires, Argentina / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. ECLAMC at Departamento de Genética. Rio de Janeiro, RJ, Brasil.
Keywords in Portuguese
Dados
Anormalidades cromossômicas
Mês de concepção
Hemisfério Sul
 
Keywords
Chromosomal abnormalities
Month of conception.
Southern hemisphere
Data
 
Publisher
Wiley
Citation
GADOW, Enrique et al. De novo chromosomal abnormalities and month of conception. Data from the southern hemisphere. Prenatal Diagnosis, v. 26, p. 1183-1189, 2006.
DOI
10.1002/pd.1586
ISSN
0197-3851
Notes
Seasonal variation studies on chromosomal abnormalities, especially Down syndrome, have been previously reported (Kallen and Masback, 1988). Different hypotheses have been made including hormonal imbalance and exposure to ionizing radiation. A very comprehensive review article on seasonal variation at birth concluded that there is no real evidence of seasonality in the birth prevalence of Down syndrome (Stolwijk et al., 1997). One of the various criticisms of the reviewed studies was that they did not take into account those fetuses with chromosomal anomalies that would be lost before term. It was, therefore, suggested that data obtained from prenatal diagnosis closer to the month of conception should be studied.