Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/39931
Title: Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-kappaB dependent mechanism
Authors: Aimbire, F.
Santos, F. V.
Albertini, R.
Faria Neto, Hugo Caire C.
Mittmann, J.
Soares, C. Pacheco
Affilliation: Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil.
Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil.
Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil.
Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos, SP, Brasil.
Abstract: Background and objective: Low-level laser therapy (LLLT) is a known modulator of inflammatory process. Herein we studied the effect of 660 nm diode laser on mRNA levels of neutrophils anti-apoptotic factors in lipopolysaccharide (LPS)-induced lung inflammation. Study design/ methodology: Mice were divided into 8 groups (n=7 for each group) and irradiated with energy dosage of 7.5 J/cm2. The Bcl-xL and A1 mRNA levels in neutrophils were evaluated by Real Time- PCR (RT-PCR). The animals were irradiated after exposure time of LPS. Results: LLLT and an inhibitor of NF-κB nuclear translocation (BMS 205820) attenuated the mRNA levels of Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS-induced inflammation. Conclusion: LLLT reduced the levels of anti-apoptotic factors in LPS inflamed mice lung neutrophils by an action mechanism in which the NF-κB seems to be involved.
Keywords: Neutrófilos pulmonares
Terapia a laser de baixo nível
Fatores anti-apoptóticos
NF-κB
Keywords in spanish: Low-level laser therapy
Anti-apoptotic factors
Lung neutrophils
NF-κB
Issue Date: 2008
Publisher: Elsevier
Citation: AIMBIRE, F. et al. Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-κB dependent mechanism. International Immunopharmacology, v. 8, p. 603-605, 2008.
DOI: 10.1016/j.intimp.2007.12.007
ISSN: 1567-5769
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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