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Title: Genomic signatures and co-occurrence patterns of the ultra-small Saccharimonadia (phylum CPR/Patescibacteria) suggest a symbiotic lifestyle
Authors: Lemos, Leandro Nascimento
Medeiros, Julliane D.
Dini‐Andreote, Francisco
Fernandes, Gabriel Rocha
Varani, Alessandro de Mello
Oliveira, Guilherme Corrêa de
Pylro, Victor Satler
Affilliation: Universidade de São Paulo. Centro de Energia Nuclear na Agricultura. Laboratório de Biologia Celular e Molecular. Piracicaba, SP, Brasil
Universidade Federal de Juiz de Fora. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil
Department of Plant Science. The Pennsylvania State University. University Park. PA, USA/Huck Institutes of the Life Sciences. The Pennsylvania State University. University Park. PA, USA
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Informática e Genômica da Biosystems. Belo Horizonte, MG, Brasil
Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias. Departamento de Tecnologia. Jaboticabal, SP, Brazil
Instituto Tecnológico Vale. Grupo de Genômica Ambiental. Belém, PA, Brasil
Universidade Federal de Lavras. Departamento de Biologia. Laboratório de Ecologia Microbiana e Bioinformática. Lavras, MG, Brazil
Abstract: The size of bacterial genomes is often associated with organismal metabolic capabilities determining ecological breadth and lifestyle. The recently proposed Candidate Phyla Radiation (CPR)/Patescibacteria encompasses mostly unculturable bacterial taxa with relatively small genome sizes with potential for co‐metabolism interdependencies. As yet, little is known about the ecology and evolution of CPR, particularly with respect to how they might interact with other taxa. Here, we reconstructed two novel genomes (namely, Candidatus Saccharibacter sossegus and Candidatus Chaer renensis) of taxa belonging to the class Saccharimonadia within the CPR/Patescibacteria using metagenomes obtained from acid mine drainage (AMD). By testing the hypothesis of genome streamlining or symbiotic lifestyle, our results revealed clear signatures of gene losses in these genomes, such as those associated with de novo biosynthesis of essential amino acids, nucleotides, fatty acids and cofactors. In addition, co‐occurrence analysis provided evidence supporting potential symbioses of these organisms with Hydrotalea sp. in the AMD system. Together, our findings provide a better understanding of the ecology and evolution of CPR/Patescibacteria and highlight the importance of genome reconstruction for studying metabolic interdependencies between unculturable Saccharimonadia representatives.
Keywords: acid mine drainage
metagenome‐assembled genome
Issue Date: 2019
Publisher: Blackwell Publishing
Citation: LEMOS, Leandro Nascimento et al. Genomic signatures and co-occurrence patterns of the ultra-small Saccharimonadia (phylum CPR/Patescibacteria) suggest a symbiotic lifestyle. Molecular Ecology, v. 28, 18, 2019
DOI: 10.1111/mec.15208
ISSN: 0962-1083
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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