Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/39934
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dc.contributor.authorCosta, H. F.
dc.contributor.authorSantos, C. R. Bezerra
dc.contributor.authorBarbosa Filho, J. M.
dc.contributor.authorMartins, M. A.
dc.contributor.authorPiuvezam, M. R.
dc.date.accessioned2020-02-13T17:14:59Z
dc.date.available2020-02-13T17:14:59Z
dc.date.issued2008
dc.identifier.citationCOSTA, H. F. et al. Warifteine, a bisbenzylisoquinoline alkaloid, decreases immediate allergic and thermal hyperalgesic reactions in sensitized animals. International Immunopharmacology, v. 8, p. 519-525, 2008.
dc.identifier.issn1567-5769
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/39934
dc.language.isoeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subject.otherCissampelos sympodialis
dc.subject.otherAlcalóide de bisbenzilisoquinolina
dc.subject.otherMastócitos
dc.subject.otherImunoglobulina E
dc.subject.otherComportamento de arranhões
dc.subject.otherHiperalgesia térmica
dc.titleWarifteine, a bisbenzylisoquinoline alkaloid, decreases immediate allergic and thermal hyperalgesic reactions in sensitized animals
dc.typeArticle
dc.identifier.doi10.1016/j.intimp.2007.11.009
dc.description.abstractenWarifteine is a bisbenzylisoquinoline alkaloid isolated from the Cissampelos sympodialis Eichl (Menispermaceae). This plant is used in the folk medicine for the treatment of airway respiratory diseases. A murine model of immediate allergic reaction was used to evaluate warifteine treatment in the IgE production, leukocyte activation, thermal hyperalgesia, mast cell degranulation and scratching behavior. BALB/c mice treated with warifteine (0.4-10 mg/Kg) 1 h before OVA sensitization reduced OVA induced paw edema as well as the OVA-specific IgE serum titers as compared with non-treated and OVA-sensitized animals. Warifteine also reduced the mice death evoked by IgE-dependent anaphylactic shock reaction at 30 min after intravenous OVA challenge. To assess the effect of warifteine treatment on T cell proliferative response, spleen cells from warifteine treated or non-treated and OVA-sensitized animals were evaluated. Spleen cells from warifteine treated animals (2.0 mg/kg) did not proliferate following OVA stimulation as compared with spleen cell cultures from non-treated animals. This response may be related with the increase of NO production as observed in peritoneal macrophage cultures treated with warifteine. Thermal hyperalgesia evoked by IgE or histamine/5-hydroxytryptamine challenge was inhibited on rats at dose of 4.0 mg/kg. Warifteine treatment (0.6 or 6.0 microg/ml) also decreased the IgEalphaDNP-BSA sensitized mast degranulation after DNP-BSA challenge measured by histamine release. In addition, compound 48/80-induced scratching behavior was also sensitive to warifteine treatment. These results demonstrate for the first time that warifteine treatment reduced the allergy-associated responses.
dc.creator.affilliationUniversidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil.
dc.creator.affilliationUniversidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil.
dc.creator.affilliationUniversidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil.
dc.subject.enWarifteine
dc.subject.enCissampelos sympodialis
dc.subject.enMast cells
dc.subject.enImmunoglobulin E
dc.subject.enThermal hyperalgesia
dc.subject.enScratching behavior
dc.identifier.eissn1878-1705
Appears in Collections:IOC - Artigos de Periódicos

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