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HUMAN ACUTE CHAGAS DISEASE: CHANGES IN FACTOR VII, ACTIVATED PROTEIN C AND HEPATIC ENZYMES FROM PATIENTS OF ORAL OUTBREAKS IN PARÁ STATE (BRAZILIAN AMAZON)
Transmissão oral
Fatores de coagulação
Enzimas hepáticas
Carga parasita
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Abstract
Oral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate
changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to
oral Trypanosoma cruzi transmission. Clinical and epidemiological findings of 102 infected individuals attended in the State
of Pará from October 2013 to February 2016 were included. The most common symptoms were fever (98%), asthenia (83.3%),
face and limb edema (80.4%), headache (74.5%) and myalgia (72.5%). The hepatic enzymes alanine aminotransferase (ALT) and
aspartate aminotransferase (AST) of 30 ACD patients were higher compared with controls, and this increase was independent
of the treatment with benznidazole. Moreover, ACD individuals had higher plasma levels of activated protein C and lower levels
of factor VII of the coagulation cascade. Patients with the highest parasite load had also the most increased transaminase levels.
Also, ALT and AST were associated moderately (r = 0.429) and strongly (r = 0.595) with parasite load respectively. In conclusion,
the present study raises the possibility that a disturbance in coagulation and hepatic function may be linked to human ACD.
Keywords in Portuguese
Doença de ChagasTransmissão oral
Fatores de coagulação
Enzimas hepáticas
Carga parasita
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