Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Restricted access
Embargo date
2025-01-01
Collections
- IOC - Artigos de Periódicos [12821]
Metadata
Show full item record
ESSENTIAL ROLE OF VLA-4/VCAM-1 PATHWAY IN THE ESTABLISHMENT OF CD8+ T-CELL-MEDIATED TRYPANOSOMA CRUZI-ELICITED MENINGOENCEPHALITIS
Migração celular
Meningoencefalite
Imunossupressores
Moléculas de adesão
Author
Affilliation
Abstract
Central nervous system (CNS) damage can occur during Trypanosoma cruzi infection, especially in immunosuppressed patients. The
enhanced susceptibility of C3H/He mice to CD8-mediated acute meningoencephalitis is associated with higher up-regulation of vascular cell
adhesion molecule-1 (VCAM-1) on CNS vascular endothelia than in the less susceptible C57BL/6. Further, in vitro adhesion of activated
peripheral blood cells to CNS blood vessels was abrogated by anti-VLA-4 antibodies that also inhibited cell migration into the CNS of T.
cruzi-infected mice. Lastly, the reactivation of meningoencephalitis in immunosuppressed chronically infected mice was associated with
VCAM-1 up-regulation. Therefore, we hypothesize that VLA-4/VCAM-1 pathway plays a pivotal role in the establishment of T. cruzielicited encephalitia.
Keywords in Portuguese
Trypanosoma cruziMigração celular
Meningoencefalite
Imunossupressores
Moléculas de adesão
Share