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ArtigoDireito Autoral
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Data de embargo
2025-01-01
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- IOC - Artigos de Periódicos [12879]
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ESSENTIAL ROLE OF VLA-4/VCAM-1 PATHWAY IN THE ESTABLISHMENT OF CD8+ T-CELL-MEDIATED TRYPANOSOMA CRUZI-ELICITED MENINGOENCEPHALITIS
Migração celular
Meningoencefalite
Imunossupressores
Moléculas de adesão
Meningoencephalitis
Immunosuppressions
Adhesion molecules
Cell migration
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Afiliação
Resumo em Inglês
Central nervous system (CNS) damage can occur during Trypanosoma cruzi infection, especially in immunosuppressed patients. The
enhanced susceptibility of C3H/He mice to CD8-mediated acute meningoencephalitis is associated with higher up-regulation of vascular cell
adhesion molecule-1 (VCAM-1) on CNS vascular endothelia than in the less susceptible C57BL/6. Further, in vitro adhesion of activated
peripheral blood cells to CNS blood vessels was abrogated by anti-VLA-4 antibodies that also inhibited cell migration into the CNS of T.
cruzi-infected mice. Lastly, the reactivation of meningoencephalitis in immunosuppressed chronically infected mice was associated with
VCAM-1 up-regulation. Therefore, we hypothesize that VLA-4/VCAM-1 pathway plays a pivotal role in the establishment of T. cruzielicited encephalitia.
Palavras-chave
Trypanosoma cruziMigração celular
Meningoencefalite
Imunossupressores
Moléculas de adesão
Palavras-chave em inglês
Trypanosoma cruziMeningoencephalitis
Immunosuppressions
Adhesion molecules
Cell migration
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