| Author | Roffê, Ester | |
| Author | Silva, Andrea A. | |
| Author | Marino, Ana Paula M. P. | |
| Author | Santos, Paula A. V. dos | |
| Author | Lannes-Vieira, Joseli | |
| Access date | 2020-04-11T20:48:05Z | |
| Available date | 2020-04-11T20:48:05Z | |
| Document date | 2003 | |
| Citation | ROFFÊ, Ester et al. Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis. Journal of Neuroimmunology, v. 142, p. 17-30, 2003. | pt_BR |
| ISSN | 0165-5728 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/40711 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Migração celular | pt_BR |
| Subject in Portuguese | Meningoencefalite | pt_BR |
| Subject in Portuguese | Imunossupressores | pt_BR |
| Subject in Portuguese | Moléculas de adesão | pt_BR |
| Title | Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/S0165-5728(03)00254-6 | |
| Abstract | Central nervous system (CNS) damage can occur during Trypanosoma cruzi infection, especially in immunosuppressed patients. The
enhanced susceptibility of C3H/He mice to CD8-mediated acute meningoencephalitis is associated with higher up-regulation of vascular cell
adhesion molecule-1 (VCAM-1) on CNS vascular endothelia than in the less susceptible C57BL/6. Further, in vitro adhesion of activated
peripheral blood cells to CNS blood vessels was abrogated by anti-VLA-4 antibodies that also inhibited cell migration into the CNS of T.
cruzi-infected mice. Lastly, the reactivation of meningoencephalitis in immunosuppressed chronically infected mice was associated with
VCAM-1 up-regulation. Therefore, we hypothesize that VLA-4/VCAM-1 pathway plays a pivotal role in the establishment of T. cruzielicited encephalitia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Meningoencephalitis | pt_BR |
| Subject | Immunosuppressions | pt_BR |
| Subject | Adhesion molecules | pt_BR |
| Subject | Cell migration | pt_BR |
| e-ISSN | 1872-8421 | |
| Embargo date | 2025-01-01 | |
