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dc.contributor.authorLenzi, Henrique Leonel
dc.contributor.authorMednis, Alma D.
dc.contributor.authorDessein, Alain J.
dc.identifier.citationLENZI, H. L.; MEDNIS, A.D.; DESSEIN, A. J. Activation of human eosinophils by monokines and lymphokines: source and biochemical characteristics of the eosinophil cytotoxicity-enhancing activity produced by blood mononuclear cells. Cellular Immunology, v.94, n.2, p.333-46, Sep. 1985.
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dc.titleActivation of humaneosinophils by monokines and lymphokines: Source and biochemicalcharacteristics of the eosinophilcytotoxicity-enhancingactivityproduced by bloodmononuclearcells
dc.description.abstractenWe and others have previously reported that human blood mononuclear cells release in culture certain substances that enhance the capacity of purified human blood eosinophils to kill the antibody-coated larvae of Schistosoma mansoni. The present study shows that this eosinophil cytotoxicity-enhancing activity (ECEA) is released by monocytes and T lymphocytes. Monocytes produce ECEA in resting and in LPS-stimulated cultures; T lymphocytes release such activity when stimulated by mitogens such as concanavalin A. Furthermore, the human monocytic line U-937 also releases ECEA-like activity when stimulated by LPS. The enhancing activity produced by monocytes has been partially characterized: it is sensitive to proteolysis by trypsin, relatively heat stable, and associated with molecules that have an apparent molecular weight of 14,000 to 65,000 daltons and isoelectric points of 3.8-3.9, 4.2, 4.5, 4.8-4.9. This shows that while ECEA produced by monocytes is heterogeneous in size and charge, it is probably different from interleukin 1.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationHarvard Medical School.Departments of Pathology and Medicine, Boston, Massachusetts / Brigham and Women's Hospital. Division of Rheumatology and Immunology.Boston, Massachusetts
dc.creator.affilliationINSERM CNRS. Centre d'Immunologiede Marseille-Luminy, Marseille França
dc.subject.eneosinophil cytotoxicity-enhancing activity
dc.subject.enDrug effects
dc.subject.enSchistosoma mansoni
dc.subject.enConcanavalin A
dc.subject.decsConcanavalina A
dc.subject.decsCitotoxicidade Imunológica
dc.subject.decsLinfócitos T
dc.subject.decsSchistosoma mansoni
Appears in Collections:IOC - Artigos de Periódicos
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