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https://www.arca.fiocruz.br/handle/icict/41297
CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF THE ESSENTIAL OIL OBTAINED FROM THE LEAVES OF BACCHARIS CORIDIFOLIA DC AGAINST MULTIRESISTANT STRAINS
Escherichia coli
Pseudomonas aeruginosa
Staphylococcus aureus
Agentes antibacterianos
Óleos essenciais
Escherichia coli
Pseudomonas aeruginosa
Staphylococcus aureus
Antibacterial agents
Essential oils
Autor(es)
Freitas, Priscilla Ramos
Araújo, Ana Carolina Justino de
Barbosa, Cristina Rodrigues dos Santos
Muniz, Debora Feitosa
Rocha, Janaina Esmeraldo
Araújo Neto, José Bezerra de
Silva, Maria Milene Costa da
Pereira, Raimundo Luiz Silva
Silva, Luiz Everson da
Amaral, Wanderlei do
Deschamps, Cicero
Tintino, Saulo Relison
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
Araújo, Ana Carolina Justino de
Barbosa, Cristina Rodrigues dos Santos
Muniz, Debora Feitosa
Rocha, Janaina Esmeraldo
Araújo Neto, José Bezerra de
Silva, Maria Milene Costa da
Pereira, Raimundo Luiz Silva
Silva, Luiz Everson da
Amaral, Wanderlei do
Deschamps, Cicero
Tintino, Saulo Relison
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
Afiliação
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Bioprospecting of Semiarid and Alternative Methods. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Simulations and Molecular Spectroscopy. Cariri, CE, Brazil.
Federal University of Parana. Paraná, SC, Brazil.
Federal University of Parana. Paraná, SC, Brazil.
Federal University of Parana. Paraná, SC, Brazil.
.Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
.Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Bioprospecting of Semiarid and Alternative Methods. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Regional University of Cariri. Laboratory of Simulations and Molecular Spectroscopy. Cariri, CE, Brazil.
Federal University of Parana. Paraná, SC, Brazil.
Federal University of Parana. Paraná, SC, Brazil.
Federal University of Parana. Paraná, SC, Brazil.
.Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
.Regional University of Cariri. Laboratory of Microbiology and Molecular Biology. Cariri, CE, Brazil.
Resumo em Inglês
Essential oils are secondary metabolites with immense pharmacological potential.These substances are abundantly produced by plants of the family Asteraceae, such as Baccharis coridifolia. Previous studies have demonstrated that this species has pharmacological properties that make it a promising source of new antibacterial agents. Therefore, the present study aimed to evaluate the antibacterial and antibiotic-modulating activity of Baccharis coridifolia essential oil against multidrug-resistant (MDR) strains. The phytochemical analysis was carried out by gas chromatography coupled to Mass Spectroscopy (GC/MS), and realized the Minimum Inhibitory Concentation (MIC) and antibiotic-modulation from the microdilution method in 96-well plates. It was revealed the presence of germacrene D (23.7%), bicyclogermacrene (17.1%), and (E)-caryophyllene (8.4%) as major components. The minimum inhibitory concentration of essential oil against strains of Pseudomonas aeruginosa (512 μg/mL) and Staphylococcus aureus (128 μg/mL) demonstrated clinically relevant antibacterial activity. In addition, the combination of subinhibitory doses of the oil with conventional antibiotics showed synergism, indicating potentiation of the antibacterial effect. In conclusion, the essential oil of Baccharis coridifolia (EOBc) presented antibacterial and antibiotic-modulating activities that place this species as a source of molecules useful in the fight against bacterial resistance.
Palavras-chave
Baccharis coridifoliaEscherichia coli
Pseudomonas aeruginosa
Staphylococcus aureus
Agentes antibacterianos
Óleos essenciais
Palavras-chave em inglês
Baccharis coridifoliaEscherichia coli
Pseudomonas aeruginosa
Staphylococcus aureus
Antibacterial agents
Essential oils
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