| Author | Vinhaes, Caian L. | |
| Author | Arriaga Gutiérrez, María Belen | |
| Author | Almeida, Breno L. de | |
| Author | Oliveira, João V. | |
| Author | Santos, Cleiton S. | |
| Author | Calcagno, Juan I. | |
| Author | Carvalho, Tereza X. | |
| Author | Giovanetti, Marta | |
| Author | Alcantara, Luiz Carlos Junior | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Andrade, Bruno de Bezerril | |
| Access date | 2020-05-21T17:34:27Z | |
| Available date | 2020-05-21T17:34:27Z | |
| Document date | 2020 | |
| Citation | VINHAES, Caian L. et al. Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. Journal of Infectious Diseases, p. 1-25, Apr. 2020. Preprint. | |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/41347 | |
| Sponsorship | Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; award number: 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB; award number: PPSUS/BA-FAPESB003/2017/SESAB/CNPq/MS 5125/2017). LCJA, MG and BLA were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT) / Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE) / Ministério da Saúde (440685/2016-8) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). LCJA and ICS were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (grant no. PRES-005- FEX-17-4-2-33). The work from BBA was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). MBA received a fellowship from the FAPESB. CLV is a scientific initiation fellow from CNPq. | |
| Language | eng | en_US |
| Publisher | Oxford University Press | |
| Rights | open access | |
| Subject in Portuguese | Vírus zika | pt_BR |
| Subject in Portuguese | Recém-nascidos | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Title | Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint) | en_US |
| Type | Preprint | |
| DOI | 10.1093/infdis/jiaa197 | |
| Abstract | Zika Virus (ZIKV) is an emergent flavivirus initially considered a benign and self-limited exanthematic illness. In 2015, a new epidemic emerged in northeastern of Brazil with increased incidence of a previously rare clinical outcome, microcephaly, in newborns from mothers who were infected during pregnancy. Little is known about the immunopathogenesis of ZIKV-associated microcephaly. Understanding the inflammatory profile and degree of inflammation of persons affected with such condition is an important step towards development of innovative therapeutic strategies. Methods: A case-control study compared plasma levels of several inflammatory biomarkers from newborns with ZIKV-microcephaly, asymptomatic ZKV infection or uninfected controls. Plasma biomarkers were assessed using Luminex. A series of multidimensional analysis was performed to characterize the systemic immune activation profile of the clinical groups. Results: We identified an inflammatory signature associated with ZIKV-microcephaly that suggested an increased inflammation. Network analysis suggested that ZIKV-microcephaly is associated with imbalanced immune activation and inflammation. The cephalic perimeter was inversely proportional with the degree of inflammatory perturbation. Furthermore, a combination of plasma inflammatory biomarkers could discriminate ZIKV with microcephaly from those with ZIKV without microcephaly or uninfected neonates. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil. | |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities, Salvador, BA, Brazil / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | |
| Subject | Zika Virus | en_US |
| Subject | Newborns | en_US |
| Subject | Microcephaly | en_US |
| Subject | Inflammation | en_US |
