Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/42002
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dc.contributor.authorBiembengut, Ísis Venturi
dc.contributor.authorSouza, Tatiana de Arruda Campos Brasil de
dc.date.accessioned2020-06-30T15:12:02Z
dc.date.available2020-06-30T15:12:02Z
dc.date.issued2020
dc.identifier.citationBIEMBENGUT, Ísis Venturi; SOUZA, Tatiana de Arruda Campos Brasil de. Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 19, p. 1-4, 2020.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/42002
dc.language.isoeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subject.otherCoronavírus
dc.subject.otherCOVID-19
dc.subject.otherSARS-CoV-2
dc.titleCoagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach
dc.typeArticle
dc.identifier.doi10.1590/0074-02760200179
dc.description.abstractenSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applicability of commercially approved drugs to treat coronavirus disease-19 (COVID-19). We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV-2 Mpro and human coagulation factors thrombin and Factor Xa. Further in vitro and in vivo analysis are needed to corroborate these results.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
dc.subject.enStructure
dc.subject.enLigand binding
dc.subject.enIn silico approach
dc.subject.enCOVID-19
dc.subject.enSARS-CoV-2 Mpro
dc.subject.decsSARS-CoV-2
dc.subject.decsCOVID-19
dc.subject.decsInfecções por Coronavirus
dc.subject.decsProteínas de Transporte
dc.subject.decsSimulação por Computador
dc.subject.decsEstrutura Molecular
Appears in Collections:PR - ICC - Artigos de Periódicos

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