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PHYSICAL EXERCISE PROMOTES ASTROCYTE COVERAGE OF MICROVESSELS IN A MODEL OF CHRONIC CEREBRAL HYPOPERFUSION
Hipoperfusão cerebral
Neuroinflamação
Células da glia
Microcirculação
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Abstract
Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the immune response in the CNS and make them potential sentinels in the brain parenchyma. In addition, astrocytes coverage integrity has been related to brain homeostasis. Currently, physical exercise has been proposed as an effective intervention to promote brain function improvement. However, the neuroprotective effects of early physical exercise on the astrocyte communication with the microcirculation and the microglial activation in a chronic cerebral hypoperfusion model are still unclear. The aim of this study was to investigate the impact of early intervention with physical exercise on cognition, brain microcirculatory, and inflammatory parameters in an experimental model of chronic cerebral hypoperfusion induced by permanent bilateral occlusion of the common carotid arteries (2VO).
Keywords in Portuguese
ExercícioHipoperfusão cerebral
Neuroinflamação
Células da glia
Microcirculação
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