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TRYPANOSOMA CRUZI: CORRELATIONS OF BIOLOGICAL ASPECTS OF THE LIFE CYCLE IN MICE AND TRIATOMINES
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Neurovirulência. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Neurovirulência. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Neurovirulência. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Neurovirulência. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract
The infection pattern in Swiss mice and Triatomine bugs (Rhodnius neglectus) of eleven clones and
the original stock of a Trypanosoma cruzi isolate, derived from a naturally infected Didelphis marsupialis,
were biochemically and biologically characterized. The clones and the original isolate were in the same
zymodeme (Z1) except that two clones were found to be in zymodeme 2 when tested with G6PDH.
Although infective, neither the original isolate nor the clones were highly virulent for the mice and
lesions were only observed in mice infected with the original stock and one of the clones (F8). All clones
and the original isolate infected bugs well while only the original isolate and clones E2 and F3 yielded
high metacyclogenesis rates. An observed correlation between absence of lesions in the mammal host
and high metacyclogenesis rates in the invertebrate host suggest a evolutionary trade off i.e. a fitness
increase in one trait which is accompanied by a fitness reduction in a different one. Our results suggest
that in a species as heterogeneous as T. cruzi, a cooperation effect among the subpopulations should be
considered.
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