| Author | Cruz, Alda Maria da | |
| Author | Figueiras, Danilo V. | |
| Author | Coutinho, Ziadir | |
| Author | Mayrink, Wilson | |
| Author | Grimaldi Jr., Gabriel | |
| Author | Luca, Paula M. de | |
| Author | Mendonça, Sergio C. F. | |
| Author | Coutinho, Sergio G. | |
| Access date | 2020-10-16T20:30:07Z | |
| Available date | 2020-10-16T20:30:07Z | |
| Document date | 1999 | |
| Citation | CRUZ, Alda M. da et al. Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 4, p. 537-542, July/Aug. 1999. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44024 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose mucocutânea humana | pt_BR |
| Subject in Portuguese | Síndrome da Imunodeficiência Adquirida | pt_BR |
| Subject in Portuguese | Células CD8 + | pt_BR |
| Subject in Portuguese | Interferon-γ | pt_BR |
| Subject in Portuguese | Imunoterapia | pt_BR |
| Title | Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0074-02761999000400020 | |
| Abstract | An atypical case of acquired immunodeficiency syndrome-associated mucocutaneous lesions due to
Leishmania braziliensis is described. Many vacuolated macrophages laden with amastigote forms of the
parasite were found in the lesions. Leishmanin skin test and serology for leishmaniasis were both negative. The patient was resistant to therapy with conventional drugs (antimonial and amphotericin B).
Interestingly, remission of lesions was achieved after an alternative combined therapy of antimonial
associated with immunotherapy (whole promastigote antigens). Peripheral blood mononuclear cells
were separated and stimulated in vitro with Leishmania antigens to test the lymphoproliferative responses (LPR). Before the combined immunochemotherapy, the LPR to leishmanial antigens was negligible (stimulation index - SI=1.4). After the first course of combined therapy it became positive (SI=4.17).
The antigen responding cells were predominantly T-cells (47.5%) most of them with CD8+ phenotype
(33%). Very low CD4+ cells (2.2%) percentages were detected. The increased T-cell responsiveness to
leishmanial antigens after combined therapy was accompanied by interferon-γ (IFN-γ) production as
observed in the cell culture supernatants. In this patient, healing of the leishmaniasis lesions was associated with the induction of a specific T-cell immune response, characterized by the production of
IFN-γ and the predominance of the CD8+ phenotype among the Leishmania-reactive T-cells. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Humoral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée-Guinle. Serviço de Dermatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée-Guinle. Serviço de Dermatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Human mucocutaneous leishmaniasis | pt_BR |
| Subject | Acquired immunodeficiency syndrome | pt_BR |
| Subject | CD8+ cells | pt_BR |
| Subject | Interferon-γ | pt_BR |
| Subject | Immunotherapy | pt_BR |
| e-ISSN | 1678-8060 | |
