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CELL POPULATIONS IN LESIONS OF CUTANEOUS LEISHMANIASIS OF LEISHMANIA (L.) AMAZONENSIS-INFECTED RHESUS MACAQUES, MACACA MULATTA
Macaca mulatta
Leishmaniose experimental
Imunidade celular sistêmica e local
Macaca mulatta
Experimental leishmaniasis
Systemic and local cellular immunity
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. epartamento de Primatologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. epartamento de Primatologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
The cellular nature of the infiltrate in cutaneous lesion of rhesus monkeys experimentally infected
with Leishmania (L.) amazonensis was characterized by immunohistochemistry.
Skin biopsies from infected animals with active or healing lesions were compared to non-infected
controls (three of each type) to quantitate inflammatory cell types. Inflammatory cells (composed of a
mixture of T lymphocyte subpopulations, macrophages and a small number of natural killer cells and
granulocytes) were more numerous in active lesions than in healing ones. T-cells accounted for 44.7 ±
13.1% of the infiltrate in active lesions (versus CD2+ = 40.3 ± 5.7% in healing lesions) and T-cell
ratios favor CD8+ cells in both lesion types. The percentage of cells expressing class II antigen (HLADR+) in active lesions (95 ± 7.1%) was significantly higher (P < 0.005) from the healing lesions (42.7 ±
12.7%). Moreover, the expression of the activation molecules CD25 (≅ 16%), the receptor for interleukin2, suggests that many T cells are primed and proliferating in active lesions. Distinct histopathological
patterns were observed in lesions at biopsy, but healing lesions contained more organized epithelioid
granulomas and activated macrophages, followed by fibrotic substitution. The progression and resolution of skin lesions appears to be very similar to that observed in humans, confirming the potential for
this to be used as a viable model to study the immune response in human cutaneous leishmaniasis.
Palabras clave en portugues
Leishmania (L.) amazonensisMacaca mulatta
Leishmaniose experimental
Imunidade celular sistêmica e local
Palabras clave en ingles
Leishmania (L.) amazonensisMacaca mulatta
Experimental leishmaniasis
Systemic and local cellular immunity
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