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REPLACING OXAMNIQUINE BY PRAZIQUANTEL AGAINST SCHISTOSOMA MANSONI INFECTION IN A RURAL COMMUNITY FROM THE SUGAR-CANE ZONE OF NORTHEAST BRAZIL: AN EPIDEMIOLOGICAL FOLLOW-UP
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Abstract
A group of 52 villagers was followed-up for three years regarding Schistosoma mansoni infection.
All villagers were periodically surveyed by the Kato-Katz method. In March 1997 and March 1998 the
positives were treated with oxamniquine (15-20 mg/kg), and in March 1999, with praziquantel (60 mg/
kg). All infection indices decreased substantially between March 1999 and March 2000: prevalence of
infection (from 32.7% to 21.2%), prevalence of moderate/heavy infection (from 7.7% to 1.9%), intensity
of infection (from 23.1 epg to 7.4 epg) and reinfection (from 35.7% to 14.3%). Negativation increased
from 53.8 to 82.4. An optimistic prognostic is assumed in the short term for the introduction of praziquantel
in the study area.
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