| Author | Pizzatti, Luciana | |
| Author | Kawassaki, Aedra Carla Bufalo | |
| Author | Fadel, Bruna | |
| Author | Nogueira, Fabio C. S. | |
| Author | Evaristo, Joseph A. M. | |
| Author | Woldmar, Nicole | |
| Author | Teixeira, Géssica Tuani | |
| Author | Silva, Janaína Carla da | |
| Author | Scandolara, Thalita Basso | |
| Author | Rech, Daniel | |
| Author | Candiotto, Luciano Pessôa Zanetti | |
| Author | Silveira, Guilherme Ferreira | |
| Author | Pavanelli, Wander Rogério | |
| Author | Panis, Carolina | |
| Access date | 2020-10-30T18:32:02Z | |
| Available date | 2020-10-30T18:32:02Z | |
| Document date | 2020 | |
| Citation | PIZZATTI, Luciana et al. Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in Breast Cancer women chronically exposed. Frontiers in Oncology. v. 10, n. 1698, p. 1-11, 2020. | pt_BR |
| ISSN | 2234-943X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/44276 | |
| Language | por | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Câncer da Mama | pt_BR |
| Title | Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fonc.2020.01698 | pt_BR |
| Abstract | Deleterious effects have been widely associated with chronic pesticide exposure, including cancer development. In spite of several known consequences that pesticides can trigger in the human body, few is known regarding its impact on breast câncer women that are chronically exposed to such substances during agricultural work lifelong. In this context, the present study performed a high-throughput toxicoproteomic study in association with a bioinformatics-based design to explore new putative processes and pathways deregulated by chronic pesticide exposure in breast câncer patients. To reach this goal, we analyzed comparatively non-depleted plasma samples from exposed (n = 130) and non-occupationally exposed (n = 112) women diagnosed with breast cancer by using a label-free proteomic tool. The list of proteins differentially expressed was explored by bioinformatics and the main pathways and processes further investigated. The toxicoproteomic study revealed that women exposed to pesticides exhibited mainly downregulated events, linked to immune response, coagulation and estrogen-mediated events in relation to the unexposed ones. Further investigation shown that the identified deregulated processes and pathways correlated with significant distinct levels tumor necrosis factor alpha and interleukin 1 beta in the blood, and specific clinicopathological characteristics pointed out by bioinformatics analysis as adipose-trophic levels, menopause and intratumoral clots formation. Altogether, these findings reinforce pesticides as downregulators of several biological process and highlight that these compounds can be linked to poor prognosis in breast câncer. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Londrina. Londrina, PR, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil / Universidade Estadual de Londrina. Londrina, PR, Brasil. | pt_BR |
| Subject | Breast Neoplasms | pt_BR |
| Subject | Breast Cancer | pt_BR |
| Subject | Proteomics | pt_BR |
| Subject | Tumor Necrosis Factor-alpha | pt_BR |
| Subject | Interleukin-1beta | pt_BR |
| Subject | Signal Transduction | pt_BR |
| Subject | Estrogens | pt_BR |
| Subject | Plaguicidas | pt_BR |
| Subject in Spanish | Neoplasias de la Mama | pt_BR |
| Subject in Spanish | Proteómica | pt_BR |
| Subject in Spanish | Factor de Necrosis Tumoral alfa | pt_BR |
| Subject in Spanish | Interleucina-1beta | pt_BR |
| Subject in Spanish | Transducción de Señal | pt_BR |
| Subject in Spanish | Estrógenos | pt_BR |
| Subject in Spanish | Plaguicidas | pt_BR |
| Subject in French | Tumeurs du sein | pt_BR |
| Subject in French | Protéomique | pt_BR |
| Subject in French | Facteur de nécrose tumorale alpha | pt_BR |
| Subject in French | Interleukine-1 bêta | pt_BR |
| Subject in French | Transduction du signal | pt_BR |
| Subject in French | Oestrogènes | pt_BR |
| Subject in French | Pesticides | pt_BR |
| DeCS | Neoplasias da Mama | pt_BR |
| DeCS | Proteômica | pt_BR |
| DeCS | Fator de Necrose Tumoral alfa | pt_BR |
| DeCS | Interleucina-1beta | pt_BR |
| DeCS | Transdução de Sinais | pt_BR |
| DeCS | Estrogênios | pt_BR |
| DeCS | Praguicidas | pt_BR |
| e-ISSN | 2234-943X | |
