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MECHANISMS OF EOSINOPHIL CYTOKINE RELEASE
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Harvard Medical School. Department of Medicine. Harvard Thorndike Laboratories, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center. Boston, MA, USA
Harvard Medical School. Department of Medicine. Harvard Thorndike Laboratories, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center. Boston, MA, USA
Abstract
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist preformed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides
eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within
eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct
cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine
mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not
only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow
eosinophils with distinct abilities in innate and acquired immunity.
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