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|Title:||Mechanisms of eosinophil cytokine release|
|Authors:||Melo, Christianne Bandeira|
Weller, Peter F.
|Affilliation:||Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.|
Harvard Medical School. Department of Medicine. Harvard Thorndike Laboratories, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center. Boston, MA, USA
|Abstract:||Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist preformed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.|
|Publisher:||Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.|
|Citation:||MELO, Cristianne Bandeira; WELLER, Peter. Mechanisms of eosinophil cytokine release. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl.1, p. 73-81, 2005.|
|Appears in Collections:||IOC - Artigos de Periódicos|
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