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Title: Mechanisms of eosinophil cytokine release
Authors: Melo, Christianne Bandeira
Weller, Peter F.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Harvard Medical School. Department of Medicine. Harvard Thorndike Laboratories, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center. Boston, MA, USA
Abstract: Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist preformed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.
Keywords: Eosinophils
keywords: Degranulação
Issue Date: 2005
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
Citation: MELO, Cristianne Bandeira; WELLER, Peter. Mechanisms of eosinophil cytokine release. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl.1, p. 73-81, 2005.
DOI: 10.1590/S0074-02762005000900013
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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