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- IOC - Artigos de Periódicos [12658]
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LOW AEDES AEGYPTI VECTOR COMPETENCE FOR ZIKA VIRUS FROM VIREMIC RHESUS MACAQUES
Rhesus macaques
Zika
Viremia
Vectorial capacity
Transmission
Autor(es)
Afiliação
Resumo em Inglês
Despite worldwide e orts to understand the transmission dynamics of Zika virus (ZIKV),
scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic
human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro
on six ZIKV infected pregnant rhesus macaques at several time points, half of which were treated
with Sofosbuvir (SOF). Mosquitoes were analyzed for vector competence after 3, 7 and 14 days of
incubation. Although viremia extended up to eight days post monkey inoculation, only mosquitoes
fed on the day of the peak of viremia, recorded on day two, became infected. The influence of SOF
treatment could not be assessed because the drug was administered just after mosquito feeding on
day two. The global infection, dissemination and transmission rates were quite low (4.09%, 1.91% and
0.54%, respectively); no mosquito was infected when viremia was below 1.26 105 RNA copies/mL.
In conclusion, Ae. aegypti vector competence for ZIKV from macaques is low, likely to be due to
low viral load and the short duration of ZIKV viremia in primates suitable for infecting susceptible
mosquitoes. If ZIKV infection in human and macaques behaves similarly, transmission of the Zika
virus in nature is most strongly a ected by vector density.
Palavras-chave em inglês
Non-human primatesRhesus macaques
Zika
Viremia
Vectorial capacity
Transmission
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