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CROSSTALK BETWEEN INNATE AND T CELL ADAPTIVE IMMUNITY WITH(IN) THE MUSCLE
Macrófagos
Células dendríticas
Células T efetoras
Células T regulatórias
Polimiosite
Distrofia muscular de Duchenne
Macrophages
Dendritic cells
Effector T cells
Regulatory T cells
Polymyositis
Duchenne muscular dystrophy
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Affilliation
Abstract
Growing evidence demonstrates a continuous interaction between the immune system
and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in
dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal
muscle regeneration. Although one component of the innate immunity, the macrophage,
has been extensively studied both in disease conditions and during cell or gene therapy
strategies aiming at restoring muscular functions, much less is known about dendritic
cells and their primary immunological targets, the T lymphocytes. This review will focus
on the dendritic cells and T lymphocytes (including effector and regulatory T-cells),
emphasizing the potential cross talk between these cell types and their influence on
the structure and function of skeletal muscle.
Keywords in Portuguese
MioblastosMacrófagos
Células dendríticas
Células T efetoras
Células T regulatórias
Polimiosite
Distrofia muscular de Duchenne
Keywords
MyoblastsMacrophages
Dendritic cells
Effector T cells
Regulatory T cells
Polymyositis
Duchenne muscular dystrophy
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