Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/45673
Title: FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil
Authors: Tonini, Marco André Loureiro
Barreira, Débora Maria Pires Gonçalves
Santolin, Luciana Bueno de Freitas
Volpini, Lays Paula Bondi
Leite, José Paulo G.
Le Moullac-Vaidye, Béatrice
Le Pendu, Jacques
Spano, Liliana Cruz
Affilliation: Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.
Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.
Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.
Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
CRCINA, Inserm, Université de Nantes. France.
CRCINA, Inserm, Université de Nantes. France.
Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Laboratório de Virologia e Gastroenterite Infecciosa. Maruipe, Vitória, ES, Brasil.
Abstract: Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.
Keywords: Host susceptibility
Histo-blood group antigens (HBGAs)
Norovirus
Rotavirus
Secretor status
Polymorphisms of FUT2 and FUT3
Lewis
keywords: Suscetibilidade do hospedeiro
Antígenos do grupo histo-sangue (HBGAs)
Norovírus
Rotavírus
Polimorfismos de FUT2 e FUT3
Issue Date: 2020
Publisher: MDPI
Citation: TONINI, Marco André Loureiro et al. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil. Viruses, v. 12, 1084, 14p, Sept. 2020.
DOI: 10.3390/v12101084
ISSN: 1999-4915
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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