Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/46737
Title: GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol
Authors: Teles, Amanda Mara
Silva, João Victor Silva
Fernandes, Juan Matheus Pereira
Silva, Ana Lucia Abreu
Calabrese, Katia da Silva
Mendes Filho, Nestor Everton
Mouchrek, Adenilde Nascimento
Souza, Fernando Almeida
Affilliation: Universidade Federal do Maranhão. Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
Universidade Estadual do Maranhão. Pós-Graduação em Ciência Animal. São Luis, MA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Àgua. São Luis, MA, Brasil.
Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Àgua. São Luis, MA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Maranhão. Pós-Graduação em Ciência Animal. São Luis, MA, Brasil.
Abstract: Syzygium aromaticum has a diversity of biological activities due to the chemical compounds found in its plant products such as total phenolic compounds and flavonoids. The present work describes the chemical analysis and antimicrobial, antioxidant, and antitrypanosomal activity of the essential oil of S. aromaticum. Eugenol (53.23%) as the major compound was verified by gas chromatography-mass spectrometry. S. aromaticum essential oil was more effective against S. aureus (MIC 50 μg/mL) than eugenol (MIC 250 μg/mL). Eugenol presented higher antioxidant activity than S. aromaticum essential oil, with an EC50 of 12.66 and 78.98 µg/mL, respectively. S. aromaticum essential oil and eugenol exhibited Trypanosoma cruzi inhibitory activity, with IC50 of 28.68 ± 1.073 and 31.97 ± 1.061 μg/mL against epimastigotes and IC50 of 64.51 ± 1.658 and 45.73 ± 1.252 μg/mL against intracellular amastigotes, respectively. Both compounds presented low cytotoxicity, with S. aromaticum essential oil displaying 15.5-fold greater selectivity for the parasite than the cells. Nitrite levels in T. cruzi-stimulated cells were reduced by essential oil (47.01%;  = 0.002) and eugenol (48.05%;  = 0.003) treatment. The trypanocidal activity of S. aromaticum essential oil showed that it is reasonable to use it in future research in the search for new therapeutic alternatives for trypanosomiasis.
Keywords: Syzygium aromaticum
Antibacterial activity
Antioxidant activity
Antitrypanosomal Activity
GC-MS Characterization
Essential Oil
Eugenol
keywords: Syzygium aromaticum
Atividade antibacteriana
Atividade antioxidante
Antitripanossômica
Óleo essencial
Eugenol
Caracterização por GC-MS
Issue Date: 2021
Publisher: Hindawi
Citation: TELES, Amanda Mara et al. GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol. Evidence-Based Complementary and Alternative Medicine, v. 2021, Article ID 666.3255, 12p, Feb. 2021.
DOI: 10.1155/2021/6663255
ISSN: 1741-427X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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