Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/47608
Title: Evaluation of urine SARS-COV-2 RT-PCR as a predictor of acute kidney injury and disease severity in patients with critical COVID-19
Authors: Souza, Sergio Pinto de
Silveira, Marcelo Augusto Duarte
Souza, Bruno Solano de Freitas
Cabral, Julia Barros
Melo, Erica Batista dos Santos Galvão de
Nonaka, Carolina Kymie Vasques
Coelho, Fernanda Oliveira
Passos, Rogerio da Hora
Affilliation: Hospital São Rafael. Nefrologia. Salvador, BA, Brasil / Hospital Santo Antônio. Medicina Interna. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil.
Hospital São Rafael. Nefrologia. Salvador, BA, Brasil.
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto D'Or de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Hospital São Rafael. Nefrologia. Salvador, BA, Brasil.
Hospital São Rafael. Nefrologia. Salvador, BA, Brasil.
Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.
Hospital São Rafael. Nefrologia. Salvador, BA, Brasil.
Hospital São Rafael. Nefrologia. Salvador, BA, Brasil.
Abstract: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began as an outbreak in Wuhan, China and has spread rapidly across the globe. Although most infections are mild, patients with severe and critical COVID-19 infections face deterioration of respiratory function and may also have extrapulmonary manifestations, mostly affecting the kidney, digestive tract, heart, and nervous system. Here, we prospectively evaluated the presence of SARS-CoV-2 genetic material using reverse-transcription polymerase chain reaction in urine samples obtained from patients with COVID-19 receiving critical care. Among 51 included patients, we found higher serum creatinine levels, a longer hospital stay, and more frequent need for dialysis in urine-positive patients. These findings could suggest that, in predisposed patients, a direct viral cytopathic effect may contribute to a more severe disease phenotype.
Keywords: Urine
Severe acute respiratory syndrome coronavirus 2
Polymerase chain reaction
Acute kidney injury
Coronavirus disease 2019
Virus testing
keywords: Urina
Síndrome Respiratória Aguda Grave
Reação em cadeia da polimerase
Lesão renal aguda
Coronavírus
Teste de vírus
Issue Date: 2021
Publisher: SAGE Publications
Citation: SOUZA, Sergio Pinto de et al. Evaluation of urine SARS-COV-2 RT-PCR as a predictor of acute kidney injury and disease severity in patients with critical COVID-19. Journal of International Medical Research, v. 49, n. 5, p. 1-6, 14 May 2021.
DOI: 10.1177/03000605211015555
ISSN: 0300-0605
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos
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