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PLASMODIUM VIVAX METACASPASE 1 (PVMCA1) CATALYTIC DOMAIN IS CONSERVED IN FIELD ISOLATES FROM BRAZILIAN AMAZON
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In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain in
two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among
all P. vivax field isolates and the Sal-1 reference strain. Analysis of PvMCA1 catalytic domain in different P. vivax genomic
sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions
that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was
herein predicted by molecular modeling. The genetic conservation presented by PvMCA1 may contribute to its eligibility as a
druggable target candidate in vivax malaria.
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