| Author | Sá, Nathalia Beatriz Ramos de | |
| Author | Silva, Karina dos S. | |
| Author | Alves, Marcelo Ribeiro | |
| Author | Caetano, Diogo Gama | |
| Author | Côrtes, Fernanda Heloise | |
| Author | Azevedo, Suwellen S. D. de | |
| Author | Hoagland, Brenda | |
| Author | Grinsztejn, Beatriz | |
| Author | Veloso, Valdiléa G. | |
| Author | Morgado, Mariza G. | |
| Author | Teixeira, Sylvia Lopes Maia | |
| Access date | 2021-07-29T19:21:58Z | |
| Available date | 2021-07-29T19:21:58Z | |
| Document date | 2021 | |
| Citation | SÁ, Nathalia Beatriz Ramos de et al. Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers [version 1; peer review: awaiting peer review]. FI000Research, v. 10, n. 546, 18 p, July 2021. | pt_BR |
| ISSN | 2046-1402 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/48410 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Controladores de HIV | pt_BR |
| Subject in Portuguese | Carga viral | pt_BR |
| Subject in Portuguese | Antígeno CD52 | pt_BR |
| Subject in Portuguese | Inflamassomos | pt_BR |
| Title | Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers [version 1; peer review: awaiting peer review] | pt_BR |
| Type | Article | |
| DOI | 10.12688/f1000research.53683.1 | |
| Abstract | Background: HIV controllers (HICs) constitute a heterogeneous group
of HIV-1 individuals able to suppress plasma viremia to low or
undetectable levels in the absence of antiretroviral therapy. Host
genetic factors may be involved in the sustained control of viral
replication observed. We investigated the distribution and the
potential impact of human leukocyte antigens (HLA)-B and -C alleles,
killer immunoglobulin-like receptor (KIR) genes, single nucleotide
polymorphisms (SNPs) of the NLRP3, CARD8 and IL-1β inflammasome
genes, and CCR5Δ32 mutation on the viral control among HICs. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV controllers | pt_BR |
| Subject | Viral load | pt_BR |
| Subject | HLA | pt_BR |
| Subject | KIR | pt_BR |
| Subject | CCR5 Δ32 | pt_BR |
| Subject | Inflammasome SNPs | pt_BR |
| DeCS | Antígeno CD52 | pt_BR |
| DeCS | Canais de Potássio Corretores do Fluxo de Internalização | pt_BR |
