Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/48457
Title: Social preference is maintained in mice with impaired startle refex and glutamate/D‑serine imbalance induced by chronic cerebral toxoplasmosis
Authors: Acquarone, Mariana
Poleto, A.
Perozzo, A. F.
Gonçalves, P. F. R.
Panizzutti, R.
Menezes, J. R. L.
Neves, G. A.
Barbosa, Helene Santos
Affilliation: Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.
Abstract: Toxoplasma gondii is an opportunistic protozoan pathogen with a wide geographic distribution. The chronic phase of toxoplasmosis is often asymptomatic in humans and is characterized by tissue cysts throughout the central nervous system and muscle cells. T. gondii and other pathogens with tropism for the central nervous system are considered risk factors in the etiology of several neuropsychiatric disorders, such as schizophrenia and bipolar disorder, besides neurological diseases. Currently, it is known that cerebral toxoplasmosis increases dopamine levels in the brain and it is related to behavioral changes in animals and humans. Here we evaluate whether chronic T. gondii infection, using the cystogenic ME-49 strain, could induce behavioral alterations associated with neuropsychiatric disorders and glutamatergic neurotransmission dysfunction. We observed that the startle amplitude is reduced in the infected animals as well as glutamate and D-serine levels in prefrontal cortical and hippocampal tissue homogenates. Moreover, we did not detect alterations in social preference and spontaneous alternation despite severe motor impairment. Thus, we conclude that behavioral and cognitive aspects are maintained even though severe neural damage is observed by chronic infection of C57Bl/6 mice with the ME-49 strain.
Keywords: Social preference
Mice
Startle reflex
Glutamate/D‑serine imbalance
Chronic cerebral toxoplasmosis
keywords: Camundongos
Preferência social
Reflexo de sobressalto
Desequilíbrio glutamato / D ‑ serina
Cérebro crônico toxoplasmose
Issue Date: 2021
Publisher: Nature
Citation: ACQUARONE, Mariana et al. Social preference is maintained in mice with impaired startle refex and glutamate/D‑serine imbalance induced by chronic cerebral toxoplasmosis. Scientifc Reports, v. 11, n, 14029, 9 p, 2021.
DOI: 10.1038/s41598-021-93504-1
ISSN: 2045-2322
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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