Author | Silva, Kátia Nunes da | |
Author | Gobatto, André Luiz Nunes | |
Author | Ferro, Zaquer Suzana Munhoz Costa | |
Author | Cavalcante, Bruno Raphael Ribeiro | |
Author | Caria, Alex Cleber Improta | |
Author | França, Luciana Souza de Aragão | |
Author | Nonaka, Carolina Kymie Vasques | |
Author | Lima, Fernanda de Macêdo | |
Author | Pacheco, Miquéias Lopes | |
Author | Rocco, Patricia Rieken Macêdo | |
Author | Souza, Bruno Solano de Freitas | |
Access date | 2021-09-16T13:50:21Z | |
Available date | 2021-09-16T13:50:21Z | |
Document date | 2021 | |
Citation | SILVA, Kátia Nunes da et al. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Research and Therapy, 2021. | pt_BR |
ISSN | 1757-6512 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49091 | |
Sponsorship | Serrapilheira Institute, D'Or Institute for
Research and Education (IDOR), Oswaldo Cruz Foundation (FIOCRUZ), the
Brazilian Council for Scientific and Technological Development (CNPq), the
Rio de Janeiro State Research Foundation (FAPERJ), the National Institute of
Science and Technology for Regenerative Medicine (INCT-REGENERA), and
Funding Authority for Studies and Projects (FINEP). | pt_BR |
Language | eng | pt_BR |
Publisher | BMC | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Subject in Portuguese | Pneumonia | pt_BR |
Subject in Portuguese | Células estromais | pt_BR |
Subject in Portuguese | Síndrome da angústia respiratória | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Title | Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s13287-021-02502-7 | |
Abstract | The COVID-19 pandemic, caused by the rapid global spread of the novel coronavirus (SARS-CoV-2), has caused
healthcare systems to collapse and led to hundreds of thousands of deaths. The clinical spectrum of COVID-19 is
not only limited to local pneumonia but also represents multiple organ involvement, with potential for systemic
complications. One year after the pandemic, pathophysiological knowledge has evolved, and many therapeutic
advances have occurred, but mortality rates are still elevated in severe/critical COVID-19 cases. Mesenchymal
stromal cells (MSCs) can exert immunomodulatory, antiviral, and pro-regenerative paracrine/endocrine actions and
are therefore promising candidates for MSC-based therapies. In this review, we discuss the rationale for MSC-based
therapies based on currently available preclinical and clinical evidence of safety, potential efficacy, and mechanisms
of action. Finally, we present a critical analysis of the risks, limitations, challenges, and opportunities that place MSCbased
products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce
the pandemic’s unmet medical needs. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / D’Or Institute for Research and Education. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | D’Or Institute for Research and Education. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
Affilliation | , Federal University of Bahia. Faculty of Medicine. Graduate Program in Medicine and Health. Salvador, BA, Brazil.. | pt_BR |
Affilliation | D’Or Institute for Research and Education. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | D’Or Institute for Research and Education. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil / Ministry of Science and Technology, and Innovation,COVID-19 Virus Network. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / D’Or Institute for Research and Education. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil. | pt_BR |
Subject | COVID-19 | pt_BR |
Subject | Cell therapy | pt_BR |
Subject | Mesenchymal stromal cells | pt_BR |
Subject | Acute respiratory distress syndrome | pt_BR |
Subject | SARS-CoV-2 | pt_BR |