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https://www.arca.fiocruz.br/handle/icict/49990
CELL WALL INTEGRITY PATHWAY INVOLVED IN MORPHOGENESIS, VIRULENCE AND ANTIFUNGAL SUSCEPTIBILITY IN CRYPTOCOCCUS NEOFORMANS
Cell Wall Integrity
Protein Kinase C
GTP Phosphohydrolases
Morphogenesis
Virulence
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain. / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. São Paulo, SP, Brasil.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain. / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. São Paulo, SP, Brasil.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.
Instituto de Salud Carlos III. Centro Nacional de Microbiología. Laboratório de Referência e Investigación en Micología. Madrid, Spain.
Abstract
Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell permeability and protection against stress. All these processes involve the activation of signaling pathways within the cell. The cell wall integrity (CWI) pathway is the main route responsible for maintaining the functionality and proper structure of the cell wall. This pathway is highly conserved in the fungal kingdom and has been extensively characterized in Saccharomyces cerevisiae. However, there are still many unknown aspects of this pathway in the pathogenic fungi, such as Cryptococcus neoformans. This yeast is of particular interest because it is found in the environment, but can also behave as pathogen in multiple organisms, including vertebrates and invertebrates, so it has to adapt to multiple factors to survive in multiple
niches. In this review, we summarize the components of the CWI pathway in C. neoformans as well as
its involvement in different aspects such as virulence factors, morphological changes, and its role as
target for antifungal therapies among others.
Keywords in Portuguese
GTPasesKeywords
Cell WallCell Wall Integrity
Protein Kinase C
GTP Phosphohydrolases
Morphogenesis
Virulence
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