Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Collections
- INI - Artigos de Periódicos [3041]
Metadata
Show full item record
REPLY TO "CSF CYTOKINE PROFILES DO NOT RELIABLY DELINEATE ENCEPHALOPATHY AND INFLAMMATION IN NEURO-COVID"
Author
Affilliation
Abstract
Patients presented diverse cerebrospinal fluid (CSF) profiles regarding markers
of neuroinflammation and neurodegeneration, and biochemical
and cellular findings, even among patients with the same neurological condition. The same applied to inflammatory cytokines.
On average, CSF and serum cytokine patterns were distinct,
which underscored the chronology of events triggering neurological manifestations. CSF elevation of cytokines in inflammatory
neurological diseases (IND) did not reflect a respective increase
in serum. Conversely, encephalopathy was associated with higher
serum interleukin 6, C-X-C motif chemokine ligand 8 (CXCL8),
and transforming growth factor β1 levels, but cytokines in the
CSF did not differ from controls in most cases.
Share