Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/50749
Title: SARS-CoV-2 Infections and Viral Isolations among Serially Tested Cats and Dogs in Households with Infected Owners in Texas, USA
Authors: Hamer, Sarah A.
Corrêa, Alex Pauvolid
Zecca, Italo B.
Davila, Edward
Auckland, Lisa A.
Roundy, Christopher M.
Tang, Wendy
Torchetti, Mia Kim
Killian, Mary Lea
Jenkins-Moore, Melinda
Mozingo, Katie
Akpalu, Yao
Ghai, Ria R.
Spengler, Jessica R.
Behravesh, Casey Barton
Fischer, Rebecca S. B.
Hamer, Gabriel L.
Affilliation: College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo / Fundação Oswaldo Cruz. Laboratório de Referência Nacional e Regional de SARS-CoV-2 - Laboratório de Referência nas Américas (OPAS/OMS). Rio de Janeiro, RJ, Brasil.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
College of Veterinary Medicine and Biomedical Sciences, Texas A&M University. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
National Veterinary Services Laboratories, USDA APHIS VS. Ames, IA 50010, USA.
Brazos County Health Department. Bryan, TX 77803, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention. Atlanta, GA 30329, USA.
School of Public Health, Texas A&M University. College Station, TX 77843, USA.
Department of Entomology, Texas A&M University and AgriLife Research. College Station, TX 77843, USA.
Abstract: Understanding the ecological and epidemiological roles of pets in the transmission of SARS-CoV-2 is critical for animal and human health, identifying household reservoirs, and predicting the potential enzootic maintenance of the virus. We conducted a longitudinal household transmission study of 76 dogs and cats living with at least one SARS-CoV-2-infected human in Texas and found that 17 pets from 25.6% of 39 households met the national case definition for SARS-CoV-2 infections in animals. This includes three out of seventeen (17.6%) cats and one out of fifty-nine (1.7%) dogs that were positive by RT-PCR and sequencing, with the virus successfully isolated from the respiratory swabs of one cat and one dog. Whole-genome sequences of SARS-CoV-2 obtained from all four PCR-positive animals were unique variants grouping with genomes circulating among people with COVID-19 in Texas. Re-sampling showed persistence of viral RNA for at least 25 d-post initial test. Additionally, seven out of sixteen (43.8%) cats and seven out of fifty-nine (11.9%) dogs harbored SARS-CoV-2 neutralizing antibodies upon initial sampling, with relatively stable or increasing titers over the 2–3 months of follow-up and no evidence of seroreversion. The majority (82.4%) of infected pets were asymptomatic. ‘Reverse zoonotic’ transmission of SARS-CoV-2 from infected people to animals may occur more frequently than recognized.
Keywords: SARS-CoV-2
Cats
Dogs
Reverse zoonosis
Virus isolation
Neutralizing antibodies
COVID-19
keywords: SARS-CoV-2
Gatos
Cães
Zoonose reversa
Isolamento de vírus
Anticorpos neutralizantes
COVID-19
Issue Date: 2021
Publisher: MDPI
Citation: HAMER, Sarah A. et al. SARS-CoV-2 Infections and Viral Isolations among Serially Tested Cats and Dogs in Households with Infected Owners in Texas, USA. Viruses, v. 13, 938, p. 1-16, May 2021.
DOI: 10.3390/v13050938
ISSN: 1999-4915
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
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