| Author | Paranaíba, Larissa Ferreira | |
| Author | Soares, Rodrigo Pedro Pinto | |
| Author | Guarneri, Alessandra Aparecida | |
| Access date | 2022-02-14T12:22:30Z | |
| Available date | 2022-02-14T12:22:30Z | |
| Document date | 2021 | |
| Citation | PARANAÍBA, Larissa Ferreira; SOARES, Rodrigo Pedro Pinto; GUARNERI, Alessandra Aparecida. Triatoma infestans susceptibility to different Trypanosoma cruzi strains: parasite development and early escape from anterior midgut. Parasitology, v. 148, n. 3, p. 295-301, 2021.doi: 10.1017/S0031182020001699 | pt_BR |
| ISSN | 0031-1820 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51166 | |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Triatoma infestans susceptibility to different Trypanosoma cruzi strains: parasite development and early escape from anterior midgut | pt_BR |
| Type | Article | pt_BR |
| Abstract | The escape kinetics from the anterior midgut (AM) of Trypanosoma cruzi during the initial steps of infection was assessed in Triatoma infestans, as well as its ability to survive migration in the digestive tract of the vector. All the four strains evaluated survived and reached variable parasite densities. After 49-50 days, YuYu [discrete typing units (DTU) I] strain reached the highest parasite numbers in the rectum followed by Bug (DTU V), CL-Brener (DTU VI) and Dm28c (DTU I). All strains accomplished metacyclogenesis. Bug strain reached the highest numbers of metacyclic trypomastigotes followed by YuYu and CL-Brener/Dm28c. A remarkable parasite reduction in the AM for Bug strain, but not Dm28c was noticed at 72 h of infection. In the posterior midgut + rectum high densities of parasites from both strains were detected at this period indicating the parasites crossed the AM. For Dm28c strain, in infections initiated with trypomastigotes, parasites left AM faster than those starting with epimastigotes. In conclusion, T. cruzi strains from different DTUs were able to infect T. infestans reaching variable parasite densities. The kinetics of migration in the digestive tract may be affected by strain and/or the evolutive form used for infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Parasite development | pt_BR |
| Subject | Triatoma infestans | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | parasite–vector interaction | pt_BR |
| Subject | strains | pt_BR |
