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AutorSantos, Luara Isabela Dos
AutorTorres, Thais Abdala
AutorDiniz, Suelen Queiroz
AutorGonçalves, Ricardo
AutorCaballero-Flores, Gustavo
AutorNúñez, Gabriel
AutorGazzinelli, Ricardo Tostes
AutorMaloy, Kevin Joseph
AutorAntonelli, Lis Ribeiro do Valle
Fecha de acceso2022-02-14T18:10:09Z
Fecha de disponibilización2022-02-14T18:10:09Z
Fecha de publicación2021
ReferenciaSANTOS, Luara Isabela dos et al. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular. Pathogen Cell Rep., v. 34, n. 2, 108613, 2021. doi: 10.1016/j.celrep.2020.108613.pt_BR
ISSN2211-1247pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/51186
Idiomaengpt_BR
EditorCell Presspt_BR
Derechos de autoropen accesspt_BR
TítuloDisrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogenpt_BR
Tipo del documentoArticlept_BR
Resumen en InglésIndividuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistencept_BR
AfiliaciónInstituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/ Sir William Dunn School of Pathology. University of Oxford. Oxford, OX1, UK.pt_BR
AfiliaciónInstituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.pt_BR
AfiliaciónInstituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.pt_BR
AfiliaciónDepartamento de Patologia Geral. ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minhas Gerais, Brazil.pt_BR
AfiliaciónDepartment of Pathology and Rogel Cancer Center. University of Michigan Medical School. Ann Arbor, MI, USA.pt_BR
AfiliaciónDepartment of Pathology and Rogel Cancer Center. University of Michigan Medical School. Ann Arbor, MI, USA.pt_BR
AfiliaciónInstituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil/ Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Worcester, MA, USA.pt_BR
AfiliaciónSir William Dunn School of Pathology. University of Oxford. Oxford, OX1, UK/Institute of Infection, Immunity and Inflammation. University of Glasgow. Glasgow, Scotland.pt_BR
AfiliaciónInstituto René Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil.pt_BR
Palavras clave en InglêsCitrobacter rodentiumpt_BR
Palavras clave en InglêsGram-negative bacteriapt_BR
Palavras clave en InglêsPlasmodiumpt_BR
Palavras clave en Inglêsco-infectionpt_BR
Palavras clave en Inglêshemept_BR
Palavras clave en Inglêshemolysispt_BR
Palavras clave en Inglêsironpt_BR
Palavras clave en Inglêsmalariapt_BR
Palavras clave en Inglêsmortalitypt_BR


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