Author | Peliganga, Luis Baião | |
Author | Horta, Marco Aurélio Pereira | |
Author | Lewis-Ximenez, Lia Laura | |
Access date | 2022-02-17T21:05:03Z | |
Available date | 2022-02-17T21:05:03Z | |
Document date | 2022 | |
Citation | PELIGANGA, Luis Baião et al. Enduring Challenges despite Progress in Preventing Mother-to-Child Transmission of Hepatitis B Virus in Angola. Pathogens, v. 11, 225, p. 1 - 16, Feb. 2022. | pt_BR |
ISSN | 2076-0817 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/51280 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | |
Subject in Portuguese | Vírus da Hepatite B | pt_BR |
Subject in Portuguese | Eliminação | pt_BR |
Subject in Portuguese | Transmissão de mãe para filho | pt_BR |
Subject in Portuguese | Profilaxia | pt_BR |
Subject in Portuguese | Vacinação do recém-nascido | pt_BR |
Subject in Portuguese | Gravidez | pt_BR |
Subject in Portuguese | Transmissão vertical | pt_BR |
Subject in Portuguese | Transmissão horizontal | pt_BR |
Subject in Portuguese | Infecção aguda por hepatite B | pt_BR |
Subject in Portuguese | Angola | pt_BR |
Title | Enduring Challenges despite Progress in Preventing Mother-to-Child Transmission of Hepatitis B Virus in Angola | pt_BR |
Type | Article | |
DOI | 10.3390/pathogens11020225 | |
Abstract | Sub-Saharan Africa has one of the highest rates of hepatitis B virus (HBV) infection globally,
with an incidence of 1.5 million and 0.8 million yearly deaths, which drives synergistic efforts
towards its elimination. To assess the risk of mother-to-child transmission of HBV infection, a crosssectional
study was conducted on 1012 pregnant women in Angola to investigate HBV serological
and molecular profiles. The prevalence of HBV was 8.7% (n = 88), with hepatitis B core IgM antibody
(anti-HBc IgM) positivity identified in 12.8%, hepatitis B “e” antigen (HBeAg) positivity in 30%,
and HBV DNA 200,000 IU/mL in 28.2%. Family tracking studied 44 children, of which 11 (25%)
received at least two doses of the hepatitis B vaccine. HBV was detected in 10/44 (22.7%) children,
with vaccination reported in one infected child. Further testing identified anti-HBc IgM positivity
in 3/10 (30%), HBeAg positivity in 55%, and both seromarkers in 20%. The results revealed the
importance of antenatal HBV screening, antiviral prophylaxis for mothers with high viral loads or
HBeAg positivity, and timely first-dose hepatitis B vaccines in newborns. Anti-HBc IgM positivity
among pregnant women and children highlights prophylactic measures worth considering, including
antenatal hepatitis B vaccination and catch-up vaccination to young children. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Direcção Nacional de Saúde Pública. Departamento de Controle de Doenças. Luanda, Angola / Universidade Agostinho Neto. Faculdade de Medicina. Departamento de Investigação de Medicina Interna. Luanda, Angola. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. BSL-3 Facility. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Hepatitis B virus | pt_BR |
Subject | Elimination | pt_BR |
Subject | Mother-to child transmission | pt_BR |
Subject | Prophylaxis | pt_BR |
Subject | Newborn vaccination | pt_BR |
Subject | Pregnancy | pt_BR |
Subject | Vertical transmission | pt_BR |
Subject | Horizontal transmission | pt_BR |
Subject | Acute hepatitis B infection | pt_BR |
Subject | Angola | pt_BR |