| Author | Cooper, Philip J | |
| Author | Ster, Irina Chis | |
| Author | Chico, Martha E | |
| Author | Vaca, Maritza | |
| Author | Barreto, Mauricio Lima | |
| Author | Strachan, David P | |
| Access date | 2022-02-21T17:01:28Z | |
| Available date | 2022-02-21T17:01:28Z | |
| Document date | 2021 | |
| Citation | Cooper, Philip J. et al. Patterns of allergic sensitization and factors associated with emergence of sensitization in the rural tropics early in the life course: findings of an Ecuadorian birth cohort. Frontiers Allergy, v. 2, p. 1-30, 2021. | pt_BR |
| ISSN | 2673-6101 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51340 | |
| Sponsorship | Programa de Pesquisa SCAALA (Social Changes, Asthma and Allergies in Latin America). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Alergia e Imunologia | pt_BR |
| Subject in Portuguese | Alérgenos | pt_BR |
| Title | Patterns of allergic sensitization and factors associated with emergence of sensitization in the rural tropics early in the life course: findings of an Ecuadorian birth cohort | pt_BR |
| Type | Article | pt_BR |
| DOI | doi.org/10.3389/falgy.2021.687073 | |
| Abstract | Introduction: There are limited data on emergence of allergic sensitization (or atopy) during childhood in tropical regions.
Methods: We followed a birth cohort of 2,404 newborns to 8 years in tropical Ecuador and collected: risk factor data by maternal questionnaires periodically from birth; atopy was measured by skin prick test reactivity (SPT) to aeroallergens in parents, and aeroallergens and food allergens in children at 2, 3, 5, and 8 years; and stool samples for soil-transmitted helminths (STH) from children periodically to 8 years and from parents and household members at the time of recruitment of cohort children. Data on risk factors were measured either at birth or repeatedly (time-varying) from birth to 8 years. Longitudinal repeated-measures analyses were done using generalized estimating equations to estimate the age-dependent risk of positive SPT (SPT+) to any allergen or mite during early childhood.
Results: SPT+ to any allergen was present in 29.0% of fathers and 24.8% of mothers, and in cohort children increased with age, initially to mite but later to cockroach, reaching 14.8% to any allergen (10.7% mite and 5.3% cockroach) at 8 years. Maternal SPT+, particularly presence of polysensitization (OR 2.04, 95% CI 1.49–2.77) significantly increased the risk of SPT+ during childhood, while household overcrowding at birth decreased the risk (OR 0.84, 95% CI 0.72–0.98). For mite sensitization, maternal polysensitization increased (OR 2.14, 95% CI 1.40–3.27) but rural residence (OR 0.69, 95% CI 0.50–0.94) and birth order (3rd−4th vs. 1st−2nd: OR 0.71, 95% CI 0.52–0.98) decreased the risk. Time-varying exposures to agricultural activities (OR 0.77, 95% CI 0.60–0.98) and STH parasites (OR 0.70, 95% CI 0.64–0.91) during childhood decreased while anthelmintics increased the childhood risk (OR 1.47, 95% CI 1.05–2.05) of mite sensitization.
Conclusion: Our data show the emergence of allergic sensitization, primarily to mite and cockroach allergens, during childhood in tropical Ecuador. A role for both antenatal and post-natal factors acting as potential determinants of SPT+ emergence was observed. | pt_BR |
| Affilliation | Institute of Infection and Immunity. St George's University of London. London, United Kingdom / Universidade Internacional do Equador. Escola de Medicina. Quito, Equador / Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Equador. | pt_BR |
| Affilliation | Institute of Infection and Immunity. St George's University of London. London, United Kingdom. | pt_BR |
| Affilliation | Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Equador. | pt_BR |
| Affilliation | Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Equador. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Population Health Research Institute. St George's University of London. London, United Kingdom. | pt_BR |
| Subject | Allergy and Immunology | pt_BR |
| Subject | Allergens | pt_BR |
| Subject in Spanish | Alergia e Inmunología | pt_BR |
| Subject in Spanish | Alérgenos | pt_BR |
| Subject in French | Allergie et immunologie | pt_BR |
| Subject in French | Allergènes | pt_BR |
