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HOST CHOLESTEROL INFLUENCES THE ACTIVITY OF STEROL BIOSYNTHESIS INHIBITORS IN LEISHMANIA AMAZONENSIS
Lipoproteína de baixa densidade
Colesterol
Inibidores da biossíntese de esteróis
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Abstract
A significant percentage of exogenous cholesterol was found in promastigotes and amastigotes of all studied species of
Leishmania, suggesting a biological role for this molecule. Previous studies have shown that promastigotes of Leishmania uptake
more low-density lipoprotein (LDL) particles under pharmacological pressure and are more susceptible to ergosterol inhibition
in the absence of exogenous sources of cholesterol. This work shows that the host’s LDL is available to intracellular amastigotes
and that the absence of exogenous cholesterol enhances the potency of sterol biosynthesis inhibitors in infected macrophages. A
complete understanding of cholesterol transport to the parasitophorous vacuole can guide the development of a new drug class to
be used in combination with sterol biosynthesis inhibitors for the treatment of leishmaniases.
Keywords in Portuguese
LeishmanioseLipoproteína de baixa densidade
Colesterol
Inibidores da biossíntese de esteróis
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