| Author | Andrade Neto, Valter Viana | |
| Author | Manso, Pedro Paulo de Abreu | |
| Author | Pereira, Miria Gomes | |
| Author | Cicco, Nuccia Nicole Theodoro de | |
| Author | Atella, Georgia Corrêa | |
| Author | Pelajo-Machado, Marcelo | |
| Author | Menna-Barreto, Rubem Figueiredo Sadok | |
| Author | Santos, Eduardo Caio Torres | |
| Access date | 2022-03-07T17:31:59Z | |
| Available date | 2022-03-07T17:31:59Z | |
| Document date | 2022 | |
| Citation | ANDRADE NETO, Valter Viana et al. Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220407, p. 1 - 6, 2022. | pt_BR |
| ISSN | 0074-0206 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51595 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Lipoproteína de baixa densidade | pt_BR |
| Subject in Portuguese | Colesterol | pt_BR |
| Subject in Portuguese | Inibidores da biossíntese de esteróis | pt_BR |
| Title | Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-02760220407 | |
| Abstract | A significant percentage of exogenous cholesterol was found in promastigotes and amastigotes of all studied species of
Leishmania, suggesting a biological role for this molecule. Previous studies have shown that promastigotes of Leishmania uptake
more low-density lipoprotein (LDL) particles under pharmacological pressure and are more susceptible to ergosterol inhibition
in the absence of exogenous sources of cholesterol. This work shows that the host’s LDL is available to intracellular amastigotes
and that the absence of exogenous cholesterol enhances the potency of sterol biosynthesis inhibitors in infected macrophages. A
complete understanding of cholesterol transport to the parasitophorous vacuole can guide the development of a new drug class to
be used in combination with sterol biosynthesis inhibitors for the treatment of leishmaniases. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Ultraestrutura Celular Hertha Meyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Low-density lipoprotein | pt_BR |
| Subject | Cholesterol | pt_BR |
| Subject | Sterol biosynthesis inhibitors | pt_BR |
| e-ISSN | 1678-8060 | |
