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https://www.arca.fiocruz.br/handle/icict/51693
TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF PENTACYCLIC TRITERPENES RICH FRACTION OBTAINED FROM THE LEAVES OF MANSOA HIRSUTA
Autor(es)
Pereira, Joquebede Rodrigues
Fonseca, Aldilane Gonçalves da
Fernandes, Luzia Leiros de Sena
Furtado, Allanny Alves
Silva, Valéria Costa da
Veiga Júnior, Valdir Florêncio da
Sant'Ana, Antônio Euzébio Goulart
Oliveira, Cláudia Nunes
Guerra, Gerlane Coelho Bernardo
Pedrosa, Matheus de Freitas Fernandes
Gavioli, Elaine Cristina
Costa, José Fernando Oliveira
Soares, Milena Botelho Pereira
Lima, Adley Antonini Neves de
Silva, Daniel de Melo
Lemos, Telma Maria Araújo Moura
Fonseca, Aldilane Gonçalves da
Fernandes, Luzia Leiros de Sena
Furtado, Allanny Alves
Silva, Valéria Costa da
Veiga Júnior, Valdir Florêncio da
Sant'Ana, Antônio Euzébio Goulart
Oliveira, Cláudia Nunes
Guerra, Gerlane Coelho Bernardo
Pedrosa, Matheus de Freitas Fernandes
Gavioli, Elaine Cristina
Costa, José Fernando Oliveira
Soares, Milena Botelho Pereira
Lima, Adley Antonini Neves de
Silva, Daniel de Melo
Lemos, Telma Maria Araújo Moura
Afiliação
"Múltipla ver em Notas"
Resumo em Inglês
Mansoa hirsuta is a medicinal plant native to the Brazilian semi-arid region. This approach aimed to investigate the in vitro and in vivo toxicity and anti-inflammatory and analgesic actions of the M. hirsuta fraction (MHF). In vitro cell viability was assessed in 3T3 cells. In vivo, the acute toxicity test, a single dose of the MHF was administered. For the subchronic toxicity test, three doses of were administered for 30 days. Locomotion and motor coordination were assessed using open field and rota-rod. The anti-inflammatory activity was evaluated in carrageenan-induced paw edema and zymosan-induced air-pouch models. Myeloperoxidase (MPO) and total proteins were also measured. The antinociceptive activity MHF was determined using acid acetic-induced abdominal writhing and formalin models. In the cytotoxicity assay, MHF showed no significative impairment of cell viability and in the acute toxicity study, did not cause mortality or signs of toxicity. Repeated exposure to MHF did not cause relevant toxicological changes. The evaluation in the open field test showed that the MHF did not alter the locomotor activity and there was no change in motor coordination and balance of animals. MHF significantly reduced edema, MPO production, the migration of leukocytes and protein leakage. In addition, MHF reduced abdominal writhing and significantly inhibited the first and second stage of the formalin test. The results of this study indicated that MHF has an anti-inflammatory and analgesic potential without causing acute or subchronic toxic effects and it can be a promising natural source to be explored.
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