| Author | Oliveira, Daniela Silva de | |
| Author | Medeiros, Nayara Ingrid | |
| Author | Gomes, Juliana de Assis Silva | |
| Access date | 2022-03-17T17:04:51Z | |
| Available date | 2022-03-17T17:04:51Z | |
| Document date | 2020 | |
| Citation | OLIVEIRA, Daniela Silva de; MEDEIROS, Nayara Ingrid; GOMES, Juliana de Assis Silva. Immune response in COVID-19: what do we currently know? Microbial Pathogenesis, p. 1-33, 2020. | pt_BR |
| ISSN | 0882-4010 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/51725 | |
| Description | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Previous version | https://www.arca.fiocruz.br/handle/icict/43403 | pt_BR |
| Rights | open access | pt_BR |
| Title | Immune response in COVID-19: what do we currently know? | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.micpath.2020.104484 | |
| Abstract | In 2002/2003 there was a pandemic denominate SARS (severe acute respiratory 20 syndrome), caused by the SARS-CoV virus that belongs to the genera Betacoranavirus and the family Coronaviridae, generally responsible for influenza infections. In mid of 2019, a new disease by the coronavirus named by COVID-19 (SARS-CoV-2) emerged, both infections have flu symptoms, however they are infections that variable intensity, being medium to severe. In medium infections individuals have the virus and exhibit symptoms, however hospitalization is not necessary, in severe infections, individuals are hospitalized, have high pathology and in some cases progress to death. The virus is formed by simple positive RNA, enveloped, non-segmented, and presenting the largest genome of viruses constituting 32Kb, consisting of envelope proteins, membrane, nucleo capsid and spike protein, which is essential in the interaction with the host cells. As for the origin of this virus, research has been intensified to determine this paradox and although the similarity with SARS-CoV, this virus did not has necessarily the same place of origin. As for the immune system, it is currently unknown how this new virus interacts. In this brief review, we demonstrate important considerations about the responses to this infection. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | COVID-19 | pt_BR |
| Subject | SARS-CoV-2 | pt_BR |
