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AutorAvelar, Renato Sathler
AutorAvelar, Danielle Marquete Vitelli
AutorBarbosa, Armanda Moreira Mattoso
AutorXavier, Marcelo Antônio Pascoal
AutorSantos, Silvana Maria Elói
AutorRocha, Ismael Artur da Costa
AutorCarvalho, Andréa Teixeira
AutorDick Jr, Edward J
AutorVandeBerg, Jane F
AutorVandeBerg, John L
AutorMartins Filho, Olindo Assis
Data de acesso2022-03-21T12:10:58Z
Data de disponibilização2022-03-21T12:10:58Z
Data do publicação2021
CitaçãoAVELAR, Renato Sathler et al. Phenotypic and Functional Signatures of Peripheral Blood and Spleen Compartments of Cynomolgus Macaques Infected With T. cruzi: Associations With Cardiac Histopathological Characteristics. Front Cell Infect Microbiol., v. 11, 701930, 2021. doi: 10.3389/fcimb.2021.701930.pt_BR
ISSN2235-2988pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/51760
Idiomaengpt_BR
EditorFrontiers Media ASpt_BR
Direito Autoralopen accesspt_BR
TítuloPhenotypic and Functional Signatures of Peripheral Blood and Spleen Compartments of Cynomolgus Macaques Infected With T. cruzi: Associations With Cardiac Histopathological Characteristicspt_BR
Tipo do documentoArticlept_BR
DOI10.3389/fcimb.2021.701930
Resumo em InglêsWe performed a detailed analysis of immunophenotypic features of circulating leukocytes and spleen cells from cynomolgus macaques that had been naturally infected with Trypanosoma cruzi, identifying their unique and shared characteristics in relation to cardiac histopathological lesion status. T. cruzi-infected macaques were categorized into three groups: asymptomatic [CCC(-)], with mild chronic chagasic cardiopathy [CCC(+)], or with moderate chronic chagasic cardiopathy [CCC(++)]. Our findings demonstrated significant differences in innate and adaptive immunity cells of the peripheral blood and spleen compartments, by comparison with non-infected controls. CCC(+) and CCC(++) hosts exhibited decreased frequencies of monocytes, NK and NKT-cell subsets in both compartments, and increased frequencies of activated CD8+ T-cells and GranA+/GranB+ cells. While a balanced cytokine profile (TNF/IL-10) was observed in peripheral blood of CCC(-) macaques, a predominant pro-inflammatory profile (increased levels of TNF and IFN/IL-10) was observed in both CCC(+) and CCC(++) subgroups. Our data demonstrated that cardiac histopathological features of T. cruzi-infected cynomolgus macaques are associated with perturbations of the immune system similarly to those observed in chagasic humans. These results provide further support for the validity of the cynomolgus macaque model for pre-clinical research on Chagas disease, and provide insights pertaining to the underlying immunological mechanisms involved in the progression of cardiac Chagas diseasept_BR
AfiliaçãoInstituto René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Southwest National Primate Research Center. Texas Biomedical Research Institute. San Antonio, TX, United States/Faculdade de Minas. Belo Horizonte, MG, Brazil/ Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil.pt_BR
AfiliaçãoInstituto René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Southwest National Primate Research Center. Texas Biomedical Research Institute. San Antonio, TX, United States.pt_BR
AfiliaçãoFaculdade de Minas. Belo Horizonte, MG, Brazil.pt_BR
AfiliaçãoInstituto René Rachou.Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.pt_BR
AfiliaçãoInstituto René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedêutica Complementar. Belo Horizonte, MG, Brazil.pt_BR
AfiliaçãoInstituto René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.pt_BR
AfiliaçãoInstituto René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.pt_BR
AfiliaçãoSouthwest National Primate Research Center. Texas Biomedical Research Institute. San Antonio, TX, United States.pt_BR
AfiliaçãoSouthwest National Primate Research Center. Texas Biomedical Research Institute. San Antonio, TX, United States.pt_BR
AfiliaçãoSouthwest National Primate Research Center. Texas Biomedical Research Institute. San Antonio, TX, United States/South Texas Diabetes and Obesity Institute and Department of Human Genetics. School of Medicine. The University of Texas Rio Grande Valley. Brownsville/Harlingen/Edinburg, TX, United States/Center for Vector-Borne Diseases. The University of Texas Rio Grande Valley. Brownsville/Harlingen/Edinburg, TX, United States.pt_BR
AfiliaçãoInstituto René Rachou. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.pt_BR
Palavras-chave em inglêsTrypanosoma cruzipt_BR
Palavras-chave em inglêscardiac Chagas diseasept_BR
Palavras-chave em inglêscynomolgus macaquespt_BR
Palavras-chave em inglêscytokinespt_BR
Palavras-chave em inglêsimmune responsept_BR
Palavras-chave em inglêsnon-human primatespt_BR


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