Author | Germano, Giovanna Valle | |
Author | Braga, André Flores | |
Author | Camargo, Rodrigo Mendes de | |
Author | Ballalai, Priscila Betoni | |
Author | Bezerra, Ohanna Cavalcanti | |
Author | Manta, Fernanda Saloum de Neves | |
Author | Belone, Andréa de Faria Fernandes | |
Author | Soares, Cleverson Teixeira | |
Author | Das, Pranab Kumar | |
Author | Moraes, Milton Ozório | |
Author | Latini, Ana Carla Pereira | |
Author | Souza, Vânia Niéto Brito de | |
Access date | 2022-05-01T18:24:38Z | |
Available date | 2022-05-01T18:24:38Z | |
Document date | 2022 | |
Citation | GERMANO, Giovanna Valle et al. Association of CD209 (DC-SIGN) rs735240 SNV with Paucibacillary leprosy in the Brazilian Population and its functional effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, p. 1-31, Apr. 2022. | pt_BR |
ISSN | 0074-0206 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/52492 | |
Language | eng | pt_BR |
Publisher | Fiocruz/IOC | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Mycobacterium leprae | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | Único nucleotídeo polimorfismo | pt_BR |
Subject in Portuguese | Células dendríticas | pt_BR |
Title | Association of CD209 (DC-SIGN) rs735240 SNV with Paucibacillary leprosy in the Brazilian population and its functional effects | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760220014 | |
Abstract | BACKGROUND: Leprosy, caused by Mycobacterium leprae, is a public health problem in Brazil that affects peripheral nerves, resulting in physical disabilities. During host-pathogen interactions, the immune response determines leprosy outcomes from a localized (paucibacillary) form to a disseminated (multibacillary) form. The recognition of M. leprae involves the DC-SIGN receptor, which is present on the dendritic cells (DCs) and participates in immune activation. OBJECTIVES: To evaluate the association of polymorphisms in the promoter region of the gene encoding DC-SIGN (CD209) and the clinical form of leprosy, and to investigate its functional effects. METHODS: The study population included 406 leprosy patients from an endemic area in Brazil [310 multibacillary (MB); 96 paucibacillary (PB)]. A functional evaluation based on the effects of the single nucleotide variant (SNV) associated with PB leprosy on the specific immune response was performed. RESULTS: The GA genotype and the presence of the A allele of rs735240 (-939G>A) were associated with PB leprosy [OR: 2.09 (1.18–3.69) and 1.84 (1.07–3.14), respectively]. Carriers of the A allele showed reduced expression of CD209 and TGF-β1 in leprosy lesions in comparison with individuals with GG genotype, in addition to a higher response to the Mitsuda test. CONCLUSION: These data suggest that rs735240 influences the immune response against M. leprae and clinical presentation of leprosy. | pt_BR |
Affilliation | Faculdade de Medicina de Botucatu. Programa de Pós-graduação em Doenças Tropicais. Botucatu, SP, Brasil / Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina de Botucatu. Programa de Pós-graduação em Doenças Tropicais. Botucatu, SP, Brasil / Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina de Botucatu. Programa de Pós-graduação em Doenças Tropicais. Botucatu, SP, Brasil / Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | University of Birmingham. College of Medical and Dental Sciences. Division of Infection and Immunity. Department of Clinical Immunology. Edgbaston, B15 2TT, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Secretaria de Estado da Saúde. Bauru, SP, Brasil. | pt_BR |
Subject | DC-SIGN | pt_BR |
Subject | Mycobacterium leprae | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Single nucleotide polymorphism | pt_BR |
e-ISSN | 1678-8060 | |