| Author | Loukas, Alex | |
| Author | Hotez, Peter J. | |
| Author | Diemert, David | |
| Author | Yazdanbakhsh, Maria | |
| Author | McCarthy, James S. | |
| Author | Oliveira, Rodrigo Correa de | |
| Author | Croese, John | |
| Author | Bethony, Jeffrey Michael | |
| Access date | 2022-07-27T17:59:03Z | |
| Available date | 2022-07-27T17:59:03Z | |
| Document date | 2016 | |
| Citation | LOUKAS, Alex et al. Hookworm infection. Nat Rev Dis Primers, v. 2, 16088, 2016. doi: 10.1038/nrdp.2016.88. | pt_BR |
| ISSN | 2056-676X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/54021 | |
| Language | eng | pt_BR |
| Publisher | Nature Publishing Group | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Hookworm infection | pt_BR |
| Type | Article | |
| DOI | 10.1038/nrdp.2016.88 | |
| Abstract | Hookworms are soil-transmitted nematode parasites that can reside for many years in the small intestine of their human hosts; Necator americanus is the predominant infecting species. Adult worms feed on the blood of a host and can cause iron deficiency anaemia, especially in high-risk populations (children and women of childbearing age). Almost 500 million people in developing tropical countries are infected, and simulation models estimate that hookworm infection is responsible for >4 million disability-adjusted life years lost annually. Humans mount an immune response to hookworms, but it is mostly unsuccessful at removing adult worms from the bowel. Accordingly, the host switches to an immune-tolerant state that enables hookworms to reside in the gut for many years. Although anthelmintic drugs are available and widely used, their efficacy varies and the drugs do not prevent reinfection. Thus, other control strategies aimed at improving water quality, sanitation and hygiene are needed. In addition, efforts are underway to develop a human hookworm vaccine through public-private partnerships. However, hookworms could also be a resource; as hookworms have the capability to regulate the host's inflammation, researchers are experimentally infecting patients to treat some inflammatory diseases as an approach to discover new anti-inflammatory molecules. This area of endeavour might well yield new biotherapeutics for autoimmune and allergic diseases. | pt_BR |
| Affilliation | Centre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. James Cook University. Cairns, Queensland, Australia. | pt_BR |
| Affilliation | Departments of Pediatrics and Molecular Virology and Microbiology. National School of Tropical Medicine. Baylor College Of Medicine. Houston, Texas, USA./Sabin Vaccine Institute. Houston, Texas, USA/Texas Children’s Hospital Center for Vaccine Development. Houston, Texas, USA. | pt_BR |
| Affilliation | Department of Microbiology. Tropical Medicine and Immunology. George Washington University. Washington DC, USA/Sabin Vaccine Institute. Washington DC, USA. | pt_BR |
| Affilliation | Department of Parasitology. Leiden University Medical Centre. Leiden, The Netherlands. | pt_BR |
| Affilliation | Queensland Institute of Medical Research. Berghofer Medical Research Institute. Brisbane, Queensland, Australia/University of Queensland. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Centre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. James Cook University. Cairns, Queensland, Australia/Department of Gastroenterology. Prince Charles Hospital. Brisbane, Queensland, Australia | pt_BR |
| Affilliation | Department of Microbiology. Tropical Medicine and Immunology. George Washington University. Washington DC, USA. | pt_BR |
