Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/54464
Title: Direct effect of Plasmodium vivax recombinant vaccine candidates AMA-1 and MSP-1(19) on the innate immune response
Authors: Bueno, Lilian Lacerda
Fujiwara, Ricardo Toshio
Soares, Irene Silva
Braga, Érika Martins
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil
Universidade de São Paulo. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP. Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
Abstract: The recombinant apical membrane antigen 1 (AMA-1) and 19-kDa fragment of merozoite surface protein (MSP-1(19)) are the lead candidates for inclusion in a vaccine against blood stages of malaria due to encouraging protective studies in humans and animals. Despite the importance of an efficacious malaria vaccine, vaccine-related research has focused on identifying antigens that result in protective immunity rather than determining the nature of anti-malarial immune effector mechanisms. Moreover, emphasis has been placed on adaptive rather than innate immune responses. In this study, we investigated the effect of Plasmodium vivax vaccine candidates Pv-AMA-1 and Pv-MSP-1(19) on the immune response of malaria-naive donors. Maturation of dendritic cells is altered by Pv-AMA-1 but not Pv-MSP-1(19), as observed by differential expression of cell surface markers. In addition, Pv-AMA-1 induced an increased production of MIP-1 alpha/CCL3 and decreased production of TARC/CCL17 levels in both dendritic cells (DCs) and peripheral blood mononuclear cells (PBMCs). Finally, a significant pro-inflammatory response was elicited by Pv-AMA-1-stimulated PBMCs. These results suggest that the recombinant vaccine candidate Pv-AMA-1 may play a direct role on innate immune response and might be involved in parasite destruction. (C) 2007 Elsevier Ltd. All rights reserved
Keywords: Plasmodium vivax
AMA-1
MSP-1(19)
dendritic cells
cytokines
chemokines
innate immune response
Issue Date: 2008
Publisher: Elsevier Science
Citation: BUENO, Lilian Lacerda et al. Direct effect of Plasmodium vivax recombinant vaccine candidates AMA-1 and MSP-1(19) on the innate immune response. Vaccine, v. 26, n. 9, p. 1204-1213, 2008. doi: 10.1016/j.vaccine.2007.12.031.
DOI: 10.1016/j.vaccine.2007.12.031
ISSN: 0264-410X
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos
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