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ZIKV REPLICATION IS DIFFERENTIAL IN EXPLANTS AND CELLS OF HUMAN PLACENTAL WHICH IS SUPPRESSED BY HSV-2 COINFECTION
Coinfecção
Suscetibilidade placentária
Citocina
Transmissão congênita
HV-2BR
HHV-2BR
Coinfection
Placental susceptibility
Cytokine
Congenital transmission
HHV-2BR
Author
Affilliation
Abstract
During the Zika fever outbreak in Brazil in 2015–2016, only some babies from infected mothers had teratogenic
effects, suggesting that cofactors may influence congenital transmission. We investigated the ZIKV infection
profile in explants and isolated cells from full-term human placenta to infection with the Brazilian Zika virus
strain (ZIKVBR) and the effect of coinfection with the Brazilian Human alphaherpesvirus 2 strain (HSV-2BR) on
ZIKV replication. We found that the ZIKVBR infect the explants of amniotic and chorionic membranes, as well as
chorionic villi core, but not the trophoblasts layer. It was also observed that ZIKV replication was higher in
amniotic cells than chorionic and trophoblasts cells. Upon coinfection, the replication of ZIKVBR was reduced
according to exposed HSV-2BR load in trophoblasts cells and the levels of TNF-α and IL-6 cytokines were also
reduced. These findings suggest that the placental cell types and HSV-2BR coinfection may impact on ZIKV
replication.
Keywords in Portuguese
ZIKVBRCoinfecção
Suscetibilidade placentária
Citocina
Transmissão congênita
HV-2BR
Keywords
ZIKVBRHHV-2BR
Coinfection
Placental susceptibility
Cytokine
Congenital transmission
HHV-2BR
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