| Author | Lopes, Amanda de Oliveira | |
| Author | Marinho, Pedro do Nascimento | |
| Author | Medeiros, Letícia d’Ambrosio de Souza | |
| Author | Paula, Vanessa Salete de | |
| Access date | 2022-10-06T14:22:40Z | |
| Available date | 2022-10-06T14:22:40Z | |
| Document date | 2022 | |
| Citation | LOPES, Amanda de Oliveira et al. Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma. International Journal of Molecular Sciences, v. 23, 7203, p. 1 - 15, June 2022. | en_US |
| ISSN | 1422-0067 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55016 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Sarcoma de Kaposi | en_US |
| Subject in Portuguese | Herpesvírus associado ao sarcoma de Kaposi | en_US |
| Subject in Portuguese | Oncogenes | en_US |
| Title | Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma | en_US |
| Type | Article | en_US |
| DOI | 10.3390/ ijms23137203 | |
| Abstract | Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus
8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions,
including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection
and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF
72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9
(vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have
the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes
can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal Fluminense. Niterói, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal Fluminense. Niterói, RJ, Brasil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Kaposi’s sarcoma | en_US |
| Subject | Kaposi’s sarcoma associated herpesvirus | en_US |
| Subject | Oncogenes | en_US |
